Natural products are an important source for proteasome regulating agents.
Pei An1, Li-Jun Zhang1, Wei Peng2
1Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, No. 1200, Cailun Road, Pudong New Area, Shanghai 201203, China.
Summary
Natural products regulate the ubiquitin proteasome system (UPS) by degrading damaged proteins or modulating proteasome activity. This review explores over 80 natural compounds for potential therapeutic applications as proteasome regulators.
Area of Science:
- Biochemistry
- Pharmacology
- Natural Products Chemistry
Background:
- Natural medicines, particularly from China, have historically been used for disease treatment.
- The ubiquitin proteasome system (UPS) is crucial for degrading damaged proteins in eukaryotes.
- Modern research links UPS activity to the pharmacological effects of many natural medicines.
Purpose of the Study:
- To review and discuss how natural products and extracts regulate proteasome components.
- To identify potential new proteasome regulators for drug development and clinical use.
Main Methods:
- Literature search of scientific databases (CNKI, PubMed, Elsevier, etc.) using keywords 'natural product' and 'proteasome'.
- Inclusion of natural extracts, compounds, and derivatives involved in proteasome regulation.
- Exclusion of synthetic proteasome agents.
Main Results:
- Reviewed over 80 natural products and extracts from phytomedicines affecting proteasome regulation.
- Classified these natural products based on their chemical properties.
- Summarized mechanisms of action and characteristics of typical natural products as proteasome regulators.
Conclusions:
- Natural products can modulate the UPS by inducing protein degradation or directly regulating proteasome activity.
- Currently, few natural product-derived proteasome modulators are used clinically.
- Understanding proteasome modulator rules aids in discovering and developing new therapeutic agents.
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