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A human iPSC-astroglia neurodevelopmental model reveals divergent transcriptomic patterns in schizophrenia

Attila Szabo1,2,3, Ibrahim A Akkouh4,5, Matthieu Vandenberghe4,5

  • 1NORMENT Center of Excellence (CoE), Institute of Clinical Medicine, University of Oslo, and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway. attila.szabo@medisin.uio.no.

Translational Psychiatry
|October 30, 2021
PubMed
Summary

This study reveals that astrocytes derived from human stem cells show distinct gene expression patterns in schizophrenia (SCZ). These SCZ astrocytes exhibit altered calcium signaling, reduced glutamate uptake, and impaired metalloproteinase activity, highlighting astroglia

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