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Related Experiment Video

Updated: Jun 20, 2026

Expansion and Adipogenesis Induction of Adipocyte Progenitors from Perivascular Adipose Tissue Isolated by Magnetic Activated Cell Sorting

Expansion and Adipogenesis Induction of Adipocyte Progenitors from Perivascular Adipose Tissue Isolated by Magnetic Activated Cell Sorting

Published on: June 30, 2017

Adipogenic progenitors in different organs: Pathophysiological implications.

Francesca Favaretto¹, Silvia Bettini¹, Luca Busetto¹

¹Department of Medicine, Internal Medicine 3, University of Padua, via Giustiniani 2, 35128, Padua, Italy.

Reviews in Endocrine & Metabolic Disorders

|October 30, 2021

Summary

This summary is machine-generated.

Dysfunctional adipose tissue, including ectopic fat, contributes to metabolic disorders like insulin resistance and type 2 diabetes. Targeting these fat depots is crucial for preventing obesity-related complications.

Keywords:

Adipose tissue Adipose tissue-derived stromal and stem cells (ASCs)Adiposopathy Intermuscular adipose tissue (IMAT)Mesenchymal stromal cells (MSCs)Obesity Signaling

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Preparation of Adipose Progenitor Cells from Mouse Epididymal Adipose Tissues

Preparation of Adipose Progenitor Cells from Mouse Epididymal Adipose Tissues

Published on: August 25, 2020

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Last Updated: Jun 20, 2026

Expansion and Adipogenesis Induction of Adipocyte Progenitors from Perivascular Adipose Tissue Isolated by Magnetic Activated Cell Sorting

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Published on: June 30, 2017

Isolation, Expansion, and Adipogenic Induction of CD34+CD31+ Endothelial Cells from Human Omental and Subcutaneous Adipose Tissue

Isolation, Expansion, and Adipogenic Induction of CD34+CD31+ Endothelial Cells from Human Omental and Subcutaneous Adipose Tissue

Published on: July 17, 2018

Preparation of Adipose Progenitor Cells from Mouse Epididymal Adipose Tissues

Preparation of Adipose Progenitor Cells from Mouse Epididymal Adipose Tissues

Published on: August 25, 2020

Area of Science:

Metabolic physiology
Cellular biology
Endocrinology

Background:

Adipose tissue is a dynamic endocrine organ regulating energy metabolism.
It comprises adipocytes, adipose-derived stromal/stem cells (ASCs), and immune/endothelial cells.
Dysfunctional adipose tissue in obesity and aging leads to inflammation and insulin resistance.

Purpose of the Study:

To review the presence and precursors of adipose tissue in non-traditional locations (ectopic fat).
To explore interactions driving the development of organ pathologies linked to dysfunctional adipose tissue.
To highlight the role of adipose tissue in metabolic diseases.

Main Methods:

Literature review focusing on adipose tissue biology, ectopic fat, and metabolic disease.
Analysis of cellular composition and differentiation of adipose precursors.
Examination of pathological mechanisms in obesity-related diseases.

Main Results:

Obesity alters ASCs, impairing adipose tissue function and promoting systemic inflammation.
Ectopic adipose tissue forms in organs like the heart and liver when normal depots reach capacity.
Ectopic fat shares characteristics with dysfunctional adipose tissue, increasing disease risk.

Conclusions:

Dysfunctional adipose tissue, particularly ectopic fat, is implicated in insulin resistance, type 2 diabetes, and cardiovascular disease.
Understanding adipose tissue precursors and their interactions is key to preventing metabolic complications.
Targeting dysfunctional adipose tissue offers a strategy to mitigate obesity-related health issues.