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Updated: Oct 15, 2025

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Published on: September 29, 2018
Repeated infusion of autologous adipose tissue-derived stem cells for Parkinson's disease
Kazuo Shigematsu1,2, Naoyuki Komori2, Kenichi Tahara3
1Department of Neurology, Minami Kyoto Hospital, National Hospital Organization, Kyoto, Japan.
Background:
Mesenchymal stem cells are expected to have a therapeutic effect on progressive neurodegenerative diseases for which there is currently no fundamental treatment.
Aims Of The Study:
The aim is to confirm that repeated infusion of autologous adipose tissue-derived stem cells (ADSCs) can be safely administered to patients with Parkinson's disease, and to investigate the effects of this as a pilot study.
Methods:
Three patients with Parkinson's disease received five or six repeated infusions of ADSCs at intervals of approximately one month. Observations were based on medical examinations by a neurologist and interviews with the patient and caregivers. The severity of Parkinson's disease was assessed using the Hoehn & Yahr staging scale and Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS).
Results:
No adverse events were observed during the observation period from the start of treatment to six months after the end of the last dose. MDS-UPDRS improved in all three patients.
Conclusions:
Repeated administration of Autologous ADSCs for Parkinson's disease was safe and feasible. The results of this pilot study provide insight into the value of further research.
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