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Surgical Implantation of Chronic Neural Electrodes for Recording Single Unit Activity and Electrocorticographic Signals

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Published on: February 24, 2012

Long-term satisfaction after extraoperative invasive EEG recording.

Masaki Sonoda¹, Alanna Carlson², Robert Rothermel³

¹Department of Pediatrics, Children's Hospital of Michigan, Detroit Medical Center, Wayne State University, Detroit, MI 48201, USA; Department of Neurosurgery, Yokohama City University, Yokohama, Kanagawa 2360004, Japan.

Epilepsy & Behavior : E&B

|October 30, 2021

Summary

Complete removal of the seizure-onset zone (SOZ) and younger age predict long-term satisfaction after epilepsy surgery. These factors are crucial for counseling patients considering surgical interventions for drug-resistant epilepsy.

Keywords:

High-frequency oscillations (HFOs)Intracerebral EEG Pediatric epilepsy surgery Phase-amplitude coupling Ripples

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Robotic-Guided Stereoelectroencephalography for Invasive Epilepsy Monitoring

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Last Updated: Oct 15, 2025

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$Stereo-Electro-Encephalo-Graphy SEEG With Robotic Assistance in the Presurgical Evaluation of Medical Refractory Epilepsy: A Technical Note$

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Robotic-Guided Stereoelectroencephalography for Invasive Epilepsy Monitoring

Robotic-Guided Stereoelectroencephalography for Invasive Epilepsy Monitoring

Published on: June 13, 2025

Area of Science:

Neurology
Neurosurgery
Epileptology

Background:

Drug-resistant focal epilepsy presents significant challenges for patients and families.
Extraoperative intracranial EEG (iEEG) is a critical tool for localizing the seizure-onset zone (SOZ) in epilepsy surgery candidates.
Predicting long-term patient and family satisfaction after iEEG is essential for surgical decision-making.

Purpose of the Study:

To identify predictors of long-term patient and family satisfaction following extraoperative intracranial EEG (iEEG) in drug-resistant focal epilepsy.
To evaluate the utility of novel iEEG-derived metrics, including modulation index (MI) and high-gamma activity, alongside clinical factors.

Main Methods:

Retrospective cohort study of 53 patients with drug-resistant focal epilepsy.
Mixed-effects model analysis incorporating seizure-onset zone (SOZ) removal, patient age, 'subtraction-MI', and 'maximum resected high-gamma' activity.
Analysis of clinical and imaging profiles as potential predictors.

Main Results:

Complete resection of the seizure-onset zone (SOZ) was independently associated with greater long-term satisfaction (p=0.003).
Younger patient age was also independently associated with greater satisfaction (p=0.040).
'Subtraction-MI' and 'maximum naming-related high-gamma' did not show significant independent associations with satisfaction.

Conclusions:

Complete SOZ resection and younger age are key predictors of favorable long-term outcomes after epilepsy surgery.
These findings aid in counseling patients regarding the potential benefits and outcomes of epilepsy surgery.
Further research may explore other biomarkers for predicting surgical success and patient satisfaction.