Related Experiment Video

Updated: Oct 15, 2025

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment
11:13

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment

Published on: June 9, 2023

1.8K

Resveratrol mediates its anti-cancer effects by Nrf2 signaling pathway activation

Matin Alavi1, Tahereh Farkhondeh2,3, Michael Aschner4

  • 1Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Cancer Cell International
|October 31, 2021
PubMed
Abstract

Insights

Resveratrol, a natural compound, shows promise in fighting cancer by activating the Nrf2 pathway, increasing cancer cell death, and reducing proliferation. Further research is needed to fully understand its mechanisms.

Area of Science:

  • Oncology
  • Molecular Biology
  • Natural Products Chemistry

Background:

  • Cancer poses a significant global health burden with high mortality rates.
  • Current cancer therapies often exhibit limited efficacy and substantial side effects.

Purpose of the Study:

  • To review the existing literature on the anticancer effects of resveratrol.
  • To explore the role of the Nrf2 signaling pathway in resveratrol's mechanism of action against cancer.

Main Methods:

  • A comprehensive literature search was performed across major scientific databases including PubMed, Google Scholar, Scopus, and Web of Science.
  • Articles focusing on the anticancer properties of resveratrol were systematically collected and analyzed.

Main Results:

  • Resveratrol, a naturally occurring polyphenol, activates the Nuclear factor erythroid 2-related factor 2 (Nrf2) transcription factor.
  • Activation of Nrf2 by resveratrol leads to the induction of antioxidant gene expression.
  • In various cancer cell lines, resveratrol demonstrated the ability to enhance apoptosis and inhibit cell proliferation.

Conclusions:

  • Resveratrol exhibits potential as an effective agent in cancer treatment.
  • The precise mechanisms underlying resveratrol's action and its interaction with the Nrf2 signaling pathway require further in-depth investigation due to ongoing scientific debate.
Keywords:
CancerNrf2Resveratrol

More Related Videos

Establishment of Hepatocarcinoma in BALB/c-nu Mice and Investigation of the Therapeutic Effect of the Sanleng Jiashen Formula09:03

Establishment of Hepatocarcinoma in BALB/c-nu Mice and Investigation of the Therapeutic Effect of the Sanleng Jiashen Formula

Published on: January 26, 2024

495
Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells13:38

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells

Published on: January 18, 2017

12.4K

Related Concept Videos

NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
7.9K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.9K
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
6.4K
Transducer Mechanism: Nuclear Receptors01:31

Transducer Mechanism: Nuclear Receptors

Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
1.9K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.9K
Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
15.3K