Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Functional Brain Systems: Reticular Formation01:13

Functional Brain Systems: Reticular Formation

2.9K
The reticular formation is a complex network of gray and white matter located within the brainstem extending from the medulla to the midbrain.
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...
2.9K
Functional Brain Systems: Limbic System01:15

Functional Brain Systems: Limbic System

4.3K
The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
4.3K
Association Areas of the Cortex01:21

Association Areas of the Cortex

6.8K
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
6.8K
Somatosensory, Motor, and Association Cortex01:24

Somatosensory, Motor, and Association Cortex

1.2K
The somatosensory cortex in the parietal lobes is crucial for interpreting sensory data such as touch, temperature, and proprioception. The somatosensory cortex, situated in the parietal lobes, plays a vital role in interpreting sensory information like touch, temperature, and proprioception—awareness of body position. This specialized brain region features an organized structure wherein neurons at the top primarily process sensations originating from the lower body. In contrast, those at...
1.2K
Neural Circuits01:25

Neural Circuits

1.9K
Neural circuits and neuronal pools are two of the main structures found in the nervous system. Neural circuits are networks of neurons that work together to carry out a specific task or process. They consist of interconnected neurons and glial cells, which provide structural and metabolic support.
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
1.9K
Cerebrum: Anatomical Overview II01:11

Cerebrum: Anatomical Overview II

2.8K
Each cerebral hemisphere can be divided into three main regions. The outermost region, the cerebral cortex, is a thin layer (2 to 4 millimeters thick) made up of gray matter, consisting of neuron cell bodies, dendrites, glial cells, and blood vessels. The middle region, or white matter, is primarily composed of myelinated nerve fibers organized into three types of large tracts: association fibers, commissures, and projection fibers. Association fibers connect different areas within the same...
2.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Commonality and variability in functional networks in children under 5 years old.

Communications biology·2026
Same author

Shared and specific associations of amygdala nuclei volumes with PTSD symptom domains and childhood trauma: An ENIGMA-PGC PTSD mega-analysis.

Molecular psychiatry·2026
Same author

Brain activity is not only for thinking.

Current opinion in behavioral sciences·2026
Same author

Brain resting state functional connectivity changes with aerobic exercise, and mindfulness: A narrative review.

Sports medicine and health science·2026
Same author

Patterns of brain-wide associations reflect socioeconomics.

Science (New York, N.Y.)·2026
Same author

Functional brain network correlates of pubertal timing and depressive symptoms in preadolescence.

bioRxiv : the preprint server for biology·2026

Related Experiment Video

Updated: Oct 15, 2025

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms
08:36

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

Published on: March 21, 2019

7.4K

Individualized Functional Subnetworks Connect Human Striatum and Frontal Cortex.

Evan M Gordon1, Timothy O Laumann2, Scott Marek2

  • 1Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Cerebral Cortex (New York, N.Y. : 1991)
|October 31, 2021
PubMed
Summary

This study used precision functional mapping with MRI to reveal individual-specific brain networks connecting the cortex and striatum. These findings provide detailed insights into human corticostriatal connectivity, including unique language-related networks.

Keywords:
brain networksfMRIfunctional connectivityindividual variabilitystriatum

More Related Videos

Modeling the Functional Network for Spatial Navigation in the Human Brain
05:55

Modeling the Functional Network for Spatial Navigation in the Human Brain

Published on: October 13, 2023

1.2K
Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
17:06

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

26.5K

Related Experiment Videos

Last Updated: Oct 15, 2025

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms
08:36

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

Published on: March 21, 2019

7.4K
Modeling the Functional Network for Spatial Navigation in the Human Brain
05:55

Modeling the Functional Network for Spatial Navigation in the Human Brain

Published on: October 13, 2023

1.2K
Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
17:06

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

26.5K

Area of Science:

  • Neuroscience
  • Neuroimaging
  • Human Brain Connectivity

Background:

  • The striatum and cerebral cortex are crucial for neuropsychiatric conditions.
  • Primate corticostriatal connections are well-mapped invasively, but human mapping lacks precision.
  • Averaging neuroimaging data across individuals limits anatomical precision in human studies.

Purpose of the Study:

  • To precisely map individual-specific corticostriatal connections in humans noninvasively.
  • To identify distinct subnetworks linking the cortex to the striatum.
  • To compare human functional connectivity with primate tract-tracing data.

Main Methods:

  • Utilized highly sampled resting-state functional connectivity MRI.
  • Employed individual-specific precision functional mapping (PFM).
  • Mapped connections between cortical and striatal regions.

Main Results:

  • Identified ten individual-specific subnetworks between the frontal cortex and striatum.
  • Found convergence with nonhuman primate tract-tracing for most subnetworks.
  • Discovered two novel subnetworks linked to human language functions.
  • Detailed specific connections, e.g., nucleus accumbens to orbitofrontal cortex, caudate to lateral prefrontal cortex.

Conclusions:

  • Precision functional mapping reveals detailed, individual-specific corticostriatal connectivity.
  • The findings are neurobiologically plausible and align with some primate data.
  • Identified human-specific language networks within corticostriatal connections.
  • Offers a more precise understanding of brain networks relevant to neuropsychiatric disorders.