Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

357
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
357
Antibiotic Selection00:57

Antibiotic Selection

56.6K
Overview
56.6K
Targets for Drug Action: Overview01:26

Targets for Drug Action: Overview

8.1K
Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
8.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Automated genome mining predicts structural diversity and taxonomic distribution of peptide metallophores across bacteria.

eLife·2026
Same author

Computational pipeline reveals nature's untapped reservoir of halogenating enzymes.

bioRxiv : the preprint server for biology·2026
Same author

PanBGC: a pangenome-inspired framework for comparative analysis of biosynthetic gene clusters.

ISME communications·2025
Same author

Strategies for community-sourced biocuration in bioinformatics: a case study on MIBiG 4.0.

Briefings in bioinformatics·2025
Same author

The antiSMASH database version 5.

Nucleic acids research·2025
Same author

Discovery and Heterologous Expression of the Soil Metagenome-Derived Lasso Peptide Metanodin with an Unprecedented Ring Structure.

Journal of natural products·2025
Same journal

Correction to 'scSuperAnnotator: A platform for benchmarking comparison and visualizing automated cellular annotation methods for scRNA-seq data'.

Nucleic acids research·2026
Same journal

Correction to 'Differentiable partition function calculation for RNA'.

Nucleic acids research·2026
Same journal

Deployment of non-canonical splicing in tunicate genomes is mediated by divergent U2AF function and changing m6A modification in U1 and U6 snRNA.

Nucleic acids research·2026
Same journal

Bacillus subtilis DnaB forms multiple protein-protein interactions essential for DNA replication initiation.

Nucleic acids research·2026
Same journal

Multiple forms of protein-protein and DNA binding are exhibited by BrxC from the BREX phage restriction system.

Nucleic acids research·2026
Same journal

Biosynthesis of glycosylated 5-hydroxycytosine in the DNA of diverse viruses.

Nucleic acids research·2026
See all related articles

Related Experiment Video

Updated: Oct 15, 2025

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
08:58

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

7.0K

ARTS-DB: a database for antibiotic resistant targets.

Mehmet Direnç Mungan1,2, Kai Blin3, Nadine Ziemert1,2

  • 1Interfaculty Institute of Microbiology and Infection Medicine, Institute for Bioinformatics and Medical Informatics, University of Tübingen, 72076 Tübingen, Germany.

Nucleic Acids Research
|October 31, 2021
PubMed
Summary
This summary is machine-generated.

The ARTS database aids antibiotic discovery by prioritizing bacterial biosynthetic gene clusters (BGCs) using target-directed genome mining (TDGM). This tool accelerates the identification of novel antibiotics to combat drug-resistant bacteria.

More Related Videos

Antibiotic Dereplication Using the Antibiotic Resistance Platform
10:49

Antibiotic Dereplication Using the Antibiotic Resistance Platform

Published on: October 17, 2019

11.1K
Author Spotlight: Advancing Antibiotic Resistance Research Using an Efflux-Deficient Bacterial Strain and a Single-Copy Gene Expression System
05:06

Author Spotlight: Advancing Antibiotic Resistance Research Using an Efflux-Deficient Bacterial Strain and a Single-Copy Gene Expression System

Published on: January 5, 2024

783

Related Experiment Videos

Last Updated: Oct 15, 2025

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
08:58

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

7.0K
Antibiotic Dereplication Using the Antibiotic Resistance Platform
10:49

Antibiotic Dereplication Using the Antibiotic Resistance Platform

Published on: October 17, 2019

11.1K
Author Spotlight: Advancing Antibiotic Resistance Research Using an Efflux-Deficient Bacterial Strain and a Single-Copy Gene Expression System
05:06

Author Spotlight: Advancing Antibiotic Resistance Research Using an Efflux-Deficient Bacterial Strain and a Single-Copy Gene Expression System

Published on: January 5, 2024

783

Area of Science:

  • Microbiology
  • Bioinformatics
  • Drug Discovery

Background:

  • Antibiotic resistance necessitates the discovery of novel antimicrobial compounds.
  • Bacteria produce most antibiotics via biosynthetic gene clusters (BGCs).
  • Genome mining has identified millions of uncharacterized BGCs, but prioritization remains challenging.

Purpose of the Study:

  • To present the ARTS database, a resource for target-directed genome mining (TDGM).
  • To facilitate the prioritization of BGCs encoding potentially novel antibiotics.
  • To provide pre-computed analysis for over 70,000 bacterial genomes.

Main Methods:

  • Utilized self-resistance strategies to predict biological activities of natural products.
  • Developed the Antibiotic Resistant Target Seeker (ARTS) tool for TDGM.
  • Integrated ARTS results into a searchable database with advanced query functionalities.

Main Results:

  • The ARTS database offers pre-computed TDGM results for >70,000 genomes.
  • Advanced queries enable exploration of BGC proximity, duplication, and horizontal gene transfer.
  • Results are interconnected across the bacterial kingdom and linked to existing natural product databases.

Conclusions:

  • The ARTS database significantly enhances the efficiency of identifying novel antibiotic candidates.
  • It provides a valuable resource for researchers in natural product discovery and antimicrobial development.
  • Facilitates rapid exploration and prioritization of BGCs for antibiotic research.