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Related Concept Videos

RNA-seq03:21

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ER is the primary site for the maturation and folding of soluble and transmembrane secretory proteins. The calnexin cycle is a specific chaperone system that folds and assesses the confirmation of N-glycosylated proteins before they can exit the ER lumen. The primary players of this quality check pipeline are the lectins, ER-resident chaperones, and a glucosyl transferase enzyme. In case the calnexin system in the lumen fails to salvage a misfolded protein, it is transported to the cytoplasm...
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Related Experiment Video

Updated: Oct 15, 2025

A Rapid High-throughput Method for Mapping Ribonucleoproteins RNPs on Human pre-mRNA
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RNAInter v4.0: RNA interactome repository with redefined confidence scoring system and improved accessibility.

Juanjuan Kang1,2, Qiang Tang3,4, Jun He5

  • 1Affiliated Foshan Maternity & Child Healthcare Hospital, Southern Medical University (Foshan Maternity & Child Healthcare Hospital), Foshan 528000, China.

Nucleic Acids Research
|October 31, 2021
PubMed
Summary

The RNAInter database (RNA Interactome Database) is updated to version 4.0, offering a comprehensive resource for RNA interactions. This enhanced version features a refined scoring system and over 47 million entries for better research.

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Area of Science:

  • Molecular Biology
  • Bioinformatics
  • Genomics

Background:

  • Understanding RNA functions requires a centralized repository of RNA-associated interactions.
  • Existing data are fragmented across multiple resources, necessitating consolidation and confidence scoring.
  • The RNA Interactome Database (RNAInter) aims to address this by providing a unified platform.

Purpose of the Study:

  • To update and enhance the RNAInter database to version 4.0.
  • To improve data accessibility, retrieval, and confidence scoring of RNA interactions.
  • To provide a comprehensive platform for investigating the cellular RNA interactome.

Main Methods:

  • Developed a redefined confidence scoring system integrating experimental evidence, community trust, and tissue/cell type data.
  • Redesigned the database with a user-friendly interface for rapid interaction retrieval and browsing.
  • Manually curated literature and integrated six external databases, incorporating experimental and computational evidence.

Main Results:

  • RNAInter 4.0 now contains over 47 million entries, significantly expanding the available RNA interaction data.
  • The updated confidence scoring system provides a more reliable assessment of interaction reliability.
  • The redesigned interface facilitates efficient exploration of the RNA interactome.

Conclusions:

  • RNAInter 4.0 offers a more comprehensive and accessible platform for studying RNA-associated interactions.
  • The enhanced database supports system-level understanding of RNA functions and regulatory networks.
  • This resource is valuable for researchers investigating the complex landscape of cellular RNAs.