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Calcification Propensity in Serum and Cardiovascular Outcome in Peripheral Artery Disease

Marija Bojic1, Bernhard Bielesz1, Daniel Cejka2

  • 1Division of Nephrology, Medicine III, Medical University of Vienna, Austria.

Thrombosis and Haemostasis
|October 31, 2021
PubMed

Insights

The T50 test measures serum calcification propensity. Lower T50 values, indicating higher calcification propensity, are linked to major adverse cardiovascular events and cardiovascular mortality in peripheral artery disease patients.

Area of Science:

  • Cardiovascular Medicine
  • Nephrology
  • Biochemistry

Background:

  • Peripheral artery disease (PAD) is associated with increased cardiovascular risk.
  • Serum calcification propensity, measured by the T50 test, is a novel biomarker linked to cardiovascular events and mortality in various populations.
  • The role of calcification propensity in PAD patients without severe chronic kidney disease (CKD) requires further investigation.

Purpose of the Study:

  • To investigate the association between serum calcification propensity (T50 test) and major adverse cardiovascular events (MACE+) and mortality in patients with PAD.
  • To assess the predictive value of T50 test for cardiovascular outcomes in a cohort of PAD patients without severe CKD.

Main Methods:

  • A cohort of 287 patients with PAD without severe CKD was studied.
  • Serum calcification propensity was measured using the T50 test.
  • Major cardiovascular events (MACE+) and all-cause death were evaluated over a median follow-up of 4 years, and long-term mortality over 8.7 years.
  • Kaplan-Meier and Cox regression analyses were used to assess associations, with adjustments for cardiovascular risk factors (CVRFs), PAD stage, and media sclerosis.

Main Results:

  • Mean T50 time was 268 ± 63 minutes.
  • Low T50 values (high calcification propensity) were significantly associated with MACE+ (HR: 0.72; 95% CI: 0.55-0.94), an association that persisted after multivariate adjustment (HR: 0.65; CI: 0.47-0.91).
  • Cardiovascular mortality was significantly associated with T50 after multivariate adjustment (HR: 0.72; CI: 0.53-0.99), but all-cause mortality was not.

Conclusions:

  • Serum calcification propensity, as measured by the T50 test, is associated with an increased risk of major adverse cardiovascular events in patients with PAD.
  • The T50 test may serve as a valuable prognostic biomarker for cardiovascular mortality in PAD patients.
  • These findings highlight the importance of assessing calcification propensity in PAD management.

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