Related Experiment Video

Updated: Oct 15, 2025

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
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Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Published on: February 20, 2019

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Identification of the RORα Transcriptional Network Contributes to the Search for Therapeutic Targets in

Hiroshi Matsuoka1, Akihiro Michihara1

  • 1Laboratory of Genomic Function and Pathophysiology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University.

Biological & Pharmaceutical Bulletin
|November 1, 2021
PubMed

Insights

Retinoic acid receptor-related orphan receptor α (RORα) plays a key role in metabolism and development. Targeting RORα offers potential therapeutic strategies for diseases like atherosclerosis and diabetes.

Area of Science:

  • Molecular biology
  • Endocrinology
  • Genetics

Background:

  • Retinoic acid receptor-related orphan receptor α (RORα) regulates critical physiological processes like metabolism and circadian rhythms.
  • RORα deficiency in mice leads to severe atherosclerosis, characterized by low high-density lipoprotein, elevated inflammatory cytokines, and tissue damage.

Purpose of the Study:

  • To review the current literature on RORα structure and function.
  • To discuss RORα's genetic variations and its therapeutic potential in atherosclerosis.

Main Methods:

  • Literature review of studies on RORα.
  • Analysis of RORα's role in physiological processes and disease models.
  • Examination of endogenous and synthetic RORα ligands.

Main Results:

  • RORα influences development, metabolism, and circadian rhythm.
  • RORα deficiency is linked to atherosclerosis, hypoalphalipoproteinemia, and inflammation.
  • Characterization of RORα ligands enables synthetic ligand development.

Conclusions:

  • RORα is a crucial regulator of lipid metabolism and inflammation.
  • Targeting RORα presents a promising therapeutic avenue for atherosclerosis, diabetes, and dyslipidemia.
Keywords:
atherosclerosischolesterolischemiametabolismretinoic acid receptor-related orphan receptor αstatin

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