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Updated: Oct 14, 2025

The Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy rNAION
Published on: November 20, 2016
Simultaneous and Bilateral Non-Arteritic Anterior Ischaemic Optic Neuropathy and Acute Angle-Closure
Gerardo Esteban Cepeda-Ortegon1, Alan Baltazar Treviño-Herrera1, Abraham Olvera-Barrios1
1Department of Ophthalmology, University Hospital 'Dr. José Eleuterio González' and Faculty of Medicine, Autonomous University of Nuevo Leon (UANL), Monterrey, México.
Abstract:
Non-arteritic anterior ischaemic optic neuropathy (NAION) is the second most common cause of permanent optic nerve-related visual loss in adults after glaucoma. NAION is caused by complex mechanisms that lead to optic nerve head hypoperfusion and is frequently associated with cardiovascular risk factors like type 2 diabetes mellitus (DM2) and hypertension. An attack of acute angle-closure (AAC) occurs when the trabecular meshwork is blocked with peripheral iris that causes an abrupt rise in intraocular pressure, which can trigger a decrease in optic nerve head perfusion. We present a case with simultaneous and bilateral AAC and NAION in association with uncontrolled DM2.
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