Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Esophageal Varices-II: Clinical Features and Management01:28

Esophageal Varices-II: Clinical Features and Management

173
Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
173
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists01:28

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

292
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates...
292
Esophageal Varices-I: Introduction01:24

Esophageal Varices-I: Introduction

429
Esophageal varices are dilated, tortuous veins which are found mainly in the submucosa of the lower esophagus but which may also appear higher up or extend into the stomach. They develop due to increased pressure in the portal venous system, often as a result of liver cirrhosis. This condition scars and damages the liver, impeding normal blood flow through the portal vein. To compensate, blood seeks alternative pathways, forming fragile new vessels (varices) in the esophagus and stomach. These...
429
Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents01:24

Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents

806
In the intricate landscape of the gastric lumen, excessive acid secretion disrupts the natural defense mechanisms, weakening the mucus-bicarbonate barrier. This vulnerability allows pepsin to infiltrate epithelial cells, digesting mucosal proteins and triggering erosion, leading to ulcer formation.
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
806
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

413
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
413
Lower GI Series: Barium Enema01:23

Lower GI Series: Barium Enema

591
A Barium Enema, or a lower GI series, is a specialized radiographic examination designed to visualize the lower gastrointestinal tract, specifically the colon and rectum. This procedure is instrumental in diagnosing various conditions such as colorectal cancer, polyps, diverticulosis, and inflammatory bowel disease.
Procedure Details
The examination begins by inserting a lubricated rectal tube into the patient's rectum to administer a radiopaque barium solution. The barium flow is carefully...
591

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Surgical management of thoracic impalement injuries in sub-Saharan Africa: A three-case series from Benin.

Trauma case reports·2026
Same author

Predictors of pathologic complete response in early-stage triple-negative breast cancer treated with neoadjuvant chemo-immunotherapy: a multi-institution study.

Breast cancer research and treatment·2026
Same author

The Aging Esophagus: Contraction Reserve on High-Resolution Manometry Declines With Age.

Neurogastroenterology and motility·2026
Same author

Revisiting fluoroquinolone prophylaxis in haematological malignancies and hematopoietic cell transplantation: A decade of evidence and gaps in understanding the impact of gut colonization with fluoroquinolone-resistant Enterobacterales.

International journal of antimicrobial agents·2026
Same author

Urban Residency is Independently Associated With Allergic Phenotype and Inflammatory Changes in Eosinophilic Esophagitis.

Journal of clinical gastroenterology·2026
Same author

Twelve-year utilization and outcomes of haploidentical hematopoietic stem cell transplantation (HSCT) in the Eastern Mediterranean (EM) region: A multicenter EMBMT registry analysis.

Bone marrow transplantation·2026
Same journal

Breast Mass as the Initial Presentation of B-Cell Acute Lymphoblastic Leukemia: A Case Report.

Case reports in oncology·2026
Same journal

Primary Rectal Burkitt Lymphoma in a Child: A Case Report and a Review of the Literature.

Case reports in oncology·2026
Same journal

Recurrence after Long-Term Use of Poly ADP-Ribose Polymerase Inhibitors Triggered by Therapy-Related Myeloid Neoplasms: A Case Report.

Case reports in oncology·2026
Same journal

Metastatic Involvement of the Ureter from Recurrent Pancreatic Cancer in a Patient with Multiple prior Malignancies: A Case Report.

Case reports in oncology·2026
Same journal

The Rare Trio: Concomitant Bone Marrow Involvement by Smoldering Myeloma and Systemic Mastocytosis with an Associated Hematologic Neoplasm and ALECT-2 Renal Amyloidosis - A Case Report and Literature Review.

Case reports in oncology·2026
Same journal

Gastric Metastasis with Lobular Phenotype from a Primary Invasive Ductal Breast Carcinoma: A Case Report.

Case reports in oncology·2026
See all related articles

Related Experiment Video

Updated: Oct 14, 2025

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer
06:21

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer

Published on: May 10, 2024

897

Taxane-Induced Upper Gastrointestinal Bleeding.

Yao Liu1, Brent Hiramoto1, Janet Kwok2

  • 1Department of Internal Medicine, University of Southern California ‒ Internal Medicine Residency, Los Angeles, California, USA.

Case Reports in Oncology
|November 1, 2021
PubMed
Summary
This summary is machine-generated.

Docetaxel chemotherapy can cause upper gastrointestinal bleeding, a previously unrecognized side effect. This finding suggests considering docetaxel cessation for patients experiencing melena.

Keywords:
Breast cancerChemotherapyGastrointestinal bleedTaxane

More Related Videos

Endoscopic Vacuum Therapy for the Treatment of Anastomotic Leakage after Total Gastrectomy with Esophagojejunostomy
04:05

Endoscopic Vacuum Therapy for the Treatment of Anastomotic Leakage after Total Gastrectomy with Esophagojejunostomy

Published on: August 22, 2025

158
Carotid Artery Infusions for Pharmacokinetic and Pharmacodynamic Analysis of Taxanes in Mice
08:41

Carotid Artery Infusions for Pharmacokinetic and Pharmacodynamic Analysis of Taxanes in Mice

Published on: October 27, 2014

23.3K

Related Experiment Videos

Last Updated: Oct 14, 2025

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer
06:21

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer

Published on: May 10, 2024

897
Endoscopic Vacuum Therapy for the Treatment of Anastomotic Leakage after Total Gastrectomy with Esophagojejunostomy
04:05

Endoscopic Vacuum Therapy for the Treatment of Anastomotic Leakage after Total Gastrectomy with Esophagojejunostomy

Published on: August 22, 2025

158
Carotid Artery Infusions for Pharmacokinetic and Pharmacodynamic Analysis of Taxanes in Mice
08:41

Carotid Artery Infusions for Pharmacokinetic and Pharmacodynamic Analysis of Taxanes in Mice

Published on: October 27, 2014

23.3K

Area of Science:

  • Oncology
  • Gastroenterology
  • Pharmacology

Background:

  • Docetaxel, a taxane chemotherapy agent, is widely used for various cancers.
  • Gastrointestinal side effects like nausea and diarrhea are known, but upper gastrointestinal bleeding is not documented.
  • Neutropenic enterocolitis is a severe but recognized gastrointestinal complication.

Observation:

  • A 54-year-old woman with breast cancer developed melena, dizziness, and fatigue post-docetaxel chemotherapy.
  • Esophagogastroduodenoscopy revealed gastric erosions and duodenal ulcerations/lesions.
  • Biopsies confirmed docetaxel-induced gastrointestinal toxicity.

Findings:

  • This case presents upper gastrointestinal bleeding as a novel side effect of docetaxel.
  • The patient's bleeding resolved with medical management and docetaxel discontinuation.
  • Histopathological examination supported taxane-induced mucosal damage.

Implications:

  • Upper gastrointestinal bleeding should be considered in patients on docetaxel therapy presenting with melena.
  • Early recognition may necessitate docetaxel cessation or substitution to manage bleeding.
  • This highlights the importance of monitoring for rare but serious adverse events in chemotherapy.