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The lncRNA B3GALT5-AS1 Functions as an HCC Suppressor by Regulating the miR-934/UFM1 Axis

Erlin Chen1,2, Bin Zhou3, Saiyan Bian4,5

  • 1Department of General Surgery, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu 215123, China.

Journal of Oncology
|November 1, 2021
PubMed

Insights

B3GALT5-AS1 acts as a tumor suppressor in hepatocellular carcinoma (HCC). It inhibits cancer progression by regulating miR-934 and ubiquitin-fold modifier 1 (UFM1), suggesting it as a therapeutic target for HCC.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Long noncoding RNAs (lncRNAs) are implicated in cancer development.
  • B3GALT5-AS1 expression is reduced in hepatocellular carcinoma (HCC).
  • The precise role of B3GALT5-AS1 in HCC remains unclear.

Purpose of the Study:

  • To investigate the biological function of B3GALT5-AS1 in HCC.
  • To elucidate the regulatory mechanism of B3GALT5-AS1 involving miR-934 and ubiquitin-fold modifier 1 (UFM1).

Main Methods:

  • Analysis of B3GALT5-AS1 expression in HCC tissues and cell lines.
  • Overexpression and inhibition studies of B3GALT5-AS1, miR-934, and UFM1.
  • Investigation of the PI3K/AKT signaling pathway.

Main Results:

  • B3GALT5-AS1 expression is significantly downregulated in HCC.
  • B3GALT5-AS1 overexpression inhibits HCC malignant behaviors.
  • B3GALT5-AS1 regulates miR-934 and UFM1, impacting the PI3K/AKT pathway.
  • B3GALT5-AS1 suppresses HCC cell proliferation, invasion, and metastasis.

Conclusions:

  • B3GALT5-AS1 functions as a tumor suppressor in HCC.
  • The B3GALT5-AS1/miR-934/UFM1 axis negatively regulates HCC progression.
  • B3GALT5-AS1 represents a potential therapeutic target for HCC treatment.

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