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Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
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Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

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Novel Cardiovascular Biomarkers Associated with Increased Cardiovascular Risk in Women With Prior Preeclampsia/HELLP

Esmee Me Bovee1, Martha Gulati2, Angela Hem Maas3

  • 1Radboud University Nijmegen, the Netherlands.

European Cardiology
|November 1, 2021
PubMed

Insights

Women with a history of preeclampsia or haemolysis, elevated liver enzymes and low platelets (HELLP) syndrome face higher cardiovascular disease risk. Promising biomarkers like soluble fms-like tyrosine kinase-1 and interleukins may aid in early risk stratification.

Area of Science:

  • Cardiovascular Disease Research
  • Reproductive Health Biomarkers

Background:

  • Preeclampsia and HELLP syndrome significantly increase long-term cardiovascular disease (CVD) risk in women.
  • Current guidelines for post-pregnancy CVD screening and management in these women are undefined.
  • Identifying novel cardiovascular biomarkers is crucial for predicting high-risk individuals.

Purpose of the Study:

  • To review current literature on circulating cardiovascular biomarkers associated with increased CVD risk in women with a history of preeclampsia/HELLP syndrome.
  • To identify promising biomarkers for cardiovascular risk stratification in this population.

Main Methods:

  • A narrative review of 56 studies examining 53 different biomarkers.
  • Synthesis of evidence on circulating biomarkers linked to cardiovascular risk post-preeclampsia/HELLP syndrome.

Main Results:

  • Several biomarkers demonstrated potential, including soluble fms-like tyrosine kinase-1, placental growth factor, interleukin-6 (IL-6), IL-6/IL-10 ratio, high-sensitivity cardiac troponin I, activin A, soluble human leukocyte antigen G, pregnancy-associated plasma protein A, and norepinephrine.
  • These biomarkers may be valuable for cardiovascular risk stratification.
  • Further exploration of these candidates is warranted.

Conclusions:

  • Circulating biomarkers show promise for identifying women at elevated cardiovascular risk after preeclampsia/HELLP syndrome.
  • These biomarkers could inform the development of targeted prevention strategies for hypertension and adverse events.
  • Personalized cardiovascular risk assessment may be improved through these novel markers.

Keywords:
Hypertensive disorders of pregnancybiomarkerscardiovascular diseasecardiovascular riskpreeclampsiareview

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