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Related Experiment Videos

Temporal and tissue-specific expression of mouse ets genes.

N K Bhat, R J Fisher, S Fujiwara

    Proceedings of the National Academy of Sciences of the United States of America
    |May 1, 1987
    PubMed
    Summary

    Ets-2 gene expression is closely linked to cell proliferation, showing abundance in young tissues and decreasing in differentiated ones. Hepatic regeneration reveals differential regulation of ets-1 and ets-2 genes.

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    THE RELATIONSHIP BETWEEN PERSONAL DESIRABILITY AND ENDORSEMENT WITH A FORCED-CHOICE TECHNIQUE.

    Multivariate behavioral research·2016

    Area of Science:

    • Molecular Biology
    • Gene Expression Regulation
    • Cell Proliferation

    Background:

    • The ets gene family plays a role in cellular processes.
    • Understanding ets gene expression is crucial for studying cell proliferation and differentiation.

    Purpose of the Study:

    • To investigate the expression patterns of ets-1 and ets-2 genes in mouse tissues and during liver regeneration.
    • To determine the relationship between ets gene expression and cell proliferation.

    Main Methods:

    • Analysis of ets-1 and ets-2 mRNA expression in various mouse tissues.
    • Study of gene expression during in vivo murine liver regeneration.
    • Assessment of mRNA stability using cycloheximide treatment.

    Main Results:

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    • Ets-1 and ets-2 genes are transcriptionally active, with distinct mRNA profiles and tissue distribution.
    • Both ets-1 and ets-2 mRNA are abundant in proliferating tissues and reduced in differentiated tissues (except thymus).
    • Ets-2 mRNA induction precedes DNA synthesis during liver regeneration, while ets-1 shows differential regulation.

    Conclusions:

    • Ets-2 gene expression is intrinsically linked to cell proliferation, similar to nuclear oncogenes.
    • Hepatic regeneration involves differential regulation of ets-1 and ets-2 loci.
    • Ets-2 mRNA stability is enhanced during hepatic regeneration.