Related Experiment Video
Updated: Oct 14, 2025
12:24
A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
Published on: September 30, 2021
5.5K
Prevalence of Thyroid Dysfunction in Patients With Hepatitis C
Kefayatullah Nazary1, Sana Anwar2, Ankita Y Choudhary3
1Internal Medicine, Kabul University of Medical Sciences, Kabul, AFG.
Cureus
|November 1, 2021
Summary
Hepatitis C patients show a higher frequency of thyroid dysfunction, including primary and subclinical hypothyroidism, compared to controls. Regular thyroid screening is crucial for early detection and management in hepatitis C patients.
Area of Science:
- Endocrinology
- Hepatology
- Autoimmunology
Background:
- Hepatitis C is associated with various autoimmune conditions.
- Thyroid dysfunction is a recognized complication in hepatitis C patients.
- This study investigates the link between hepatitis C and thyroid abnormalities.
Purpose of the Study:
- To determine the prevalence of thyroid dysfunction in patients with hepatitis C.
- To compare thyroid function in hepatitis C patients versus a control group.
- To identify specific types of thyroid dysfunction associated with hepatitis C.
Main Methods:
- A case-control study involving 300 hepatitis C patients and 300 controls.
- Blood samples collected for thyroid function tests.
- Study conducted from June 2020 to March 2021 at a tertiary care hospital.
Main Results:
- Hepatitis C patients exhibited a higher prevalence of primary hypothyroidism (10.6% vs. 4.6%) and subclinical hypothyroidism (6.0% vs. 1.3%) compared to controls.
- A significantly lower proportion of euthyroid patients were found in the hepatitis C group (74.6%) versus the control group (89.6%).
- Statistical significance was observed for all key findings (p-value <0.01).
Conclusions:
- Hepatitis C patients have a high incidence of thyroid dysfunction, notably primary and subclinical hypothyroidism.
- Routine thyroid function screening is recommended for early diagnosis and management in hepatitis C patients.
- Awareness of potential thyroid abnormalities is important for optimizing hepatitis C patient care.
Related Concept Videos
01:22Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
22
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
22
01:26Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow
22
Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
22
01:20Synthesis and Regulation of Thyroid Hormones
5.6K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
5.6K
01:08Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment
25
Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...
25
01:14Effect of Hepatic Disease on Pharmacokinetics: Active Drug, Metabolite and Fraction of Metabolized Drug
18
In pharmacotherapy, monitoring drug concentrations is paramount, especially for drugs whose therapeutic effects hinge on both the active compound and its metabolite. Hepatic impairment profoundly influences drug potency by altering liver function. If the drug is more potent than its metabolite, impaired liver function amplifies drug activity due to elevated drug concentration levels. Conversely, if the metabolite holds greater potency, diminished liver function diminishes drug activity by...
18
01:23The Thyroid Gland
4.7K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
4.7K