Related Experiment Video

Updated: Oct 14, 2025

A Method for Measuring RNA N6-methyladenosine Modifications in Cells and Tissues
08:56

A Method for Measuring RNA N6-methyladenosine Modifications in Cells and Tissues

Published on: December 5, 2016

11.1K

N6-Methyladenosine-Sculpted Regulatory Landscape of Noncoding RNA

Zhongyuan Zhang1, Wei Wei2, Hao Wang2

  • 1Department of Radiology, The First Affiliated Hospital of the University of Science and Technology of China, Anhui Provincial Cancer Hospital, Hefei, China.

Frontiers in Oncology
|November 1, 2021
PubMed

Insights

Dynamic N6-methyladenosine (m6A) RNA modification is crucial in mammalian cells, impacting gene expression and epigenetic regulation. This review highlights the interplay between noncoding RNAs and m6A, exploring its role in development and disease.

Area of Science:

  • Molecular Biology
  • Epigenetics
  • RNA Biology

Background:

  • N6-methyladenosine (m6A) RNA modification is a dynamic epitranscriptomic mark with significant roles in various biological and pathological processes.
  • While m6A on messenger RNAs is well-studied, its association with noncoding RNAs is less understood.
  • Noncoding RNAs (ncRNAs) modified by m6A can regulate gene expression and epigenetic mechanisms, influencing cellular functions.

Purpose of the Study:

  • To review recent advancements in understanding the biological interactions between noncoding RNAs and m6A modification.
  • To discuss the implications of these interactions in cellular development and disease.
  • To explore the potential clinical applications of targeting m6A modification.

Main Methods:

  • Literature review of recent studies on m6A modification and noncoding RNAs.
  • Analysis of the regulatory roles of m6A-modified noncoding RNAs.
  • Synthesis of findings on the interplay between ncRNAs, m6A, and biological processes.

Main Results:

  • m6A modification on noncoding RNAs influences gene expression and epigenetic regulation.
  • Noncoding RNAs can affect the homeostasis of m6A modification.
  • The interaction between ncRNAs and m6A is critical for cell development and disease progression.

Conclusions:

  • The interplay between noncoding RNAs and m6A modification is a key regulatory mechanism in cellular processes.
  • Targeting m6A modification presents potential therapeutic strategies for various diseases.
  • Further research is needed to fully elucidate the complex roles of m6A-modified noncoding RNAs.
Keywords:
N6-methyladenosine (m6A)cancernoncoding RNAspost-transcriptional modificationregulation

More Related Videos

Characterizing RNA Modifications in Single Neurons Using Mass Spectrometry08:45

Characterizing RNA Modifications in Single Neurons Using Mass Spectrometry

Published on: April 21, 2022

2.5K
Methylated RNA Immunoprecipitation Assay to Study m5C Modification in Arabidopsis08:50

Methylated RNA Immunoprecipitation Assay to Study m5C Modification in Arabidopsis

Published on: May 14, 2020

6.9K

Related Concept Videos

RNA Stability01:53

RNA Stability

Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
34.1K
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
6.9K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.0K
Chromatin Structure Regulates pre-mRNA Processing02:41

Chromatin Structure Regulates pre-mRNA Processing

In eukaryotic cells, nascent mRNA transcripts need to undergo many post-transcriptional modifications to reach the cell cytoplasm and translate into functional proteins. For a long time, transcription and pre-mRNA processing were considered two independent events that occur sequentially in the cell. However, it has now been well established that transcription and pre-mRNA processing are two simultaneous processes that are precisely regulated inside the cell.
The chromatin structure, especially...
7.4K
RNA Editing02:23

RNA Editing

RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
9.3K
Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
1.1K