Related Experiment Videos
Acute-On-Chronic Liver Failure Defined by Asian Pacific Association for the Study of the Liver Should Include
Manman Xu1,2, Ming Kong1,2, Pengfei Yu1,2
1Fourth Department of Liver Disease (Difficult & Complicated Liver Diseases and Artificial Liver Center), Beijing You'an Hospital Affiliated to Capital Medical University, Beijing, China.
Insights
Previously decompensated cirrhosis (DC) significantly increases long-term mortality in acute-on-chronic liver failure (ACLF) patients. These findings support including DC in diagnostic criteria for APASL-ACLF, improving patient management and outcomes.
Area of Science:
- Hepatology
- Internal Medicine
- Critical Care Medicine
Background:
- Acute-on-chronic liver failure (ACLF) is a severe condition with high mortality.
- The role of prior decompensated cirrhosis (DC) in diagnosing ACLF by the Asian Pacific Association for the Study of the Liver (APASL-ACLF) remains debated.
Purpose of the Study:
- To investigate the prognostic significance of decompensated cirrhosis in patients diagnosed with APASL-ACLF.
- To determine if DC impacts short-term versus long-term mortality in ACLF.
Main Methods:
- Retrospective cohort study of APASL-ACLF patients (with or without DC) from 2012-2020 across three tertiary hospitals.
- Collected baseline characteristics and survival data up to 720 days.
Main Results:
- ACLF patients with prior DC (DC-ACLF) showed significantly higher 28-, 90-, 180-, 360-, 540-, and 720-day mortality compared to those without (non-DC-ACLF).
- DC was an independent predictor of long-term (≥180 days) mortality, but not short-term (≤90 days) mortality.
- Age, total bilirubin, INR, and hepatic encephalopathy were independent risk factors for both short- and long-term mortality.
Conclusions:
- Patients with DC-ACLF experience worse prognosis, particularly concerning long-term survival.
- Decompensated cirrhosis should be incorporated into the APASL-ACLF diagnostic criteria for better patient stratification and management.
Abstract:
Background and Aims: Acute-on-chronic liver failure (ACLF) is an acute deterioration of chronic liver disease with high short-term mortality. The inclusion or exclusion of previously decompensated cirrhosis (DC) in the diagnostic criteria of ACLF defined by the Asian Pacific Association for the Study of the Liver (APASL-ACLF) has not been conclusive. We aimed to evaluate the prognostic impact of decompensated cirrhosis in ACLF. Methods: We retrospectively collected a cohort of patients with a diagnosis of APASL-ACLF (with or without DC) hospitalized from 2012 to 2020 at three liver units in tertiary hospitals. Baseline characteristics and survival data at 28, 90, 180, 360, 540, and 720 days were collected. Results: Of the patients assessed using APASL-ACLF criteria without the diagnostic indicator of chronic liver disease, 689 patients were diagnosed with ACLF, of whom 435 had no decompensated cirrhosis (non-DC-ACLF) and 254 had previously decompensated cirrhosis (DC-ACLF). The 28-, 90-, 180-, 360-, 540-, and 720-day mortality were 24.8, 42.9, 48.7, 57.3, 63.4, and 68.1%, respectively, in DC-ACLF patients, which were significantly higher than in non-DC-ACLF patients (p < 0.05). DC was independently associated with long-term (180/360/540/720 days) but not short-term (28/90 days) mortality in patients with ACLF. Age, total bilirubin, international normalized ratio, and hepatic encephalopathy were independent risk factors for short- and long-term mortality risk in ACLF patients (p < 0.05). Conclusions: Patients with DC-ACLF have a higher mortality rate, especially long-term mortality, compared to non-DC-ACLF patients. Therefore, DC should be included in the diagnostic criteria of APASL-ACLF and treated according to the ACLF management process.