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Related Concept Videos

Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

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Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
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Pulmonary Tuberculosis II01:28

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Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
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Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

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Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
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Pulmonary Tuberculosis V01:28

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Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
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Updated: Oct 14, 2025

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IFI44L as a Forward Regulator Enhancing Host Antituberculosis Responses.

Haiqin Jiang1, Lemuel Tsang2, Hongsheng Wang3

  • 1State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China.

Journal of Immunology Research
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Interferon-induced protein 44-like (IFI44L) restricts Mycobacterium tuberculosis survival in macrophages. Upregulated IFI44L expression in tuberculosis patients suggests its potential as a therapeutic target for treating this infection.

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Area of Science:

  • Immunology
  • Microbiology
  • Genetics

Background:

  • Interferon-induced protein 44-like (IFI44L) is a type I interferon-stimulated gene (ISG) with known antiviral roles.
  • The function of IFI44L in tuberculosis (TB) pathogenesis remains largely unexplored.

Purpose of the Study:

  • To investigate the role of IFI44L in human macrophages during Mycobacterium tuberculosis infection.
  • To evaluate IFI44L as a potential diagnostic or therapeutic target for tuberculosis.

Main Methods:

  • Macrophage cell culture and infection with Mycobacterium tuberculosis.
  • IFI44L gene knockdown experiments.
  • Quantitative analysis of bacterial survival and gene expression.
  • Analysis of IFI44L expression in patients with cutaneous tuberculosis (CTB) undergoing treatment.

Main Results:

  • IFI44L acts as a positive modulator and antimicrobial target in human macrophages.
  • Knockdown of IFI44L significantly increased intracellular survival of Mycobacterium tuberculosis.
  • IFI44L expression was upregulated and restricted bacterial survival post-rifampicin treatment.
  • Cutaneous tuberculosis patients showed increased IFI44L expression over 6 months of therapy.

Conclusions:

  • IFI44L promotes the clearance of Mycobacterium tuberculosis from human macrophages.
  • IFI44L exhibits antimicrobial activity, indicating its potential as a therapeutic target for tuberculosis.
  • IFI44L warrants further investigation for its diagnostic and therapeutic applications in tuberculosis.