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Published on: April 3, 2014
Short Synthesis of Molnupiravir (EIDD-2801) via a Thionated Uridine Intermediate
Raghunath Dey1, Sourav Nayak1, Parthasarathi Das1
1Department of Chemistry, Indian Institute of Technology (ISM), Dhanbad 826004, Jharkhand, India.
Abstract:
Molnupiravir (MK-4482, EIDD-2801) is an experimental drug that has been demonstrated to be effective for the treatment of COVID-19 in human clinical trials. Herein, we report a concise synthesis of the drug via a novel thionated derivative that relies on one-pot methodologies, thus decreasing the number of purification steps required. This route provides the drug in an overall 62% yield and >99% purity and uses cheap and readily available bulk chemicals, thereby providing an affordable synthesis of the drug for cheaper and wider global accessibility.
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