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Related Experiment Video

Updated: Oct 14, 2025

Lensless Fluorescent Microscopy on a Chip

Lensless Fluorescent Microscopy on a Chip

Published on: August 17, 2011

Muscope: a miniature on-chip lensless microscope.

Ekta Prajapati¹, Saurav Kumar¹, Shishir Kumar¹

¹Department of Electrical Engineering, Indian Institute of Technology, Hyderabad, 502285, India. shishirk@ee.iith.ac.in.

|November 1, 2021

Summary

This summary is machine-generated.

We developed the Muscope, a tiny lensless holographic microscope for on-chip use. This compact device achieves sub-micron resolution and enables advanced imaging without extra hardware.

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Last Updated: Oct 14, 2025

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Lensfree On-chip Tomographic Microscopy Employing Multi-angle Illumination and Pixel Super-resolution

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Compact Lens-less Digital Holographic Microscope for MEMS Inspection and Characterization

Compact Lens-less Digital Holographic Microscope for MEMS Inspection and Characterization

Published on: July 5, 2016

Area of Science:

Optics and Photonics
Microscopy
Biomedical Engineering

Background:

Lensless microscopy offers miniaturization potential but often requires complex optical setups.
On-chip integration of microscopes is crucial for portable and scalable diagnostic devices.
Existing lensless microscopes face challenges in compactness, resolution, and hardware integration.

Purpose of the Study:

To introduce the Muscope, a miniature, lensless holographic microscope designed for on-chip integration.
To demonstrate the use of a microLED display as a programmable light source for enhanced imaging.
To achieve sub-micron resolution and advanced imaging capabilities in a highly compact form factor.

Main Methods:

Developed a prototype Muscope measuring 7 mm × 4 mm × 4 mm.
Utilized a microLED display chip as a spatially addressable, microscopic light source.
Implemented computational super-resolution and wide-field imaging techniques leveraging the microLED's pixel programmability.

Main Results:

Achieved sub-micron half-pitch resolution with the miniature microscope.
Demonstrated the novel use of a microLED display as a microscope light source.
Enabled super-resolution and wide-field imaging without additional optical hardware.
Reported a new method for evaluating magnification in the lensless holographic setup.

Conclusions:

The Muscope represents a significant advancement in compact, lensless microscopy.
Its on-chip integration capability and novel light source offer advantages over existing technologies.
The Muscope opens possibilities for new devices with integrated optical imaging and sensing.