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A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors
Published on: December 7, 2014
Disseminated blastomycosis in a patient with polycythemia vera on ruxolitinib
Kristen Zeitler1, Ripal Jariwala2, Sally Alrabaa3
1Department of Pharmacy, Tampa General Hospital, Tampa, Florida, USA.
Abstract:
Ruxolitinib (RUX) is a kinase inhibitor used in the treatment of various medical conditions and its mechanism of action involves suppression of the immune system. While beneficial in treatment of polycythemia vera, myelofibrosis and other indications, it can also increase a patient's susceptibility to various infections, including bacterial, viral and fungal. We present a case of a patient being treated with RUX who presented with a disseminated fungal infection. This case emphasises the need for vigilance of endemic fungal infections in individuals who are on RUX therapy.
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