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Prognostic value of galectin-3 and right ventricular function for long-term mortality in heart failure patients

Beata Zaborska1, Ewa Pilichowska-Paszkiet2, Ewa Makowska2

  • 1Department of Cardiology, Centre of Postgraduate Medical Education, Grochowski Hospital, Grenadierów 51/59, 04-073, Warsaw, Poland. zaborska@kkcmkp.pl.

Scientific Reports
|November 2, 2021
PubMed

Insights

High galectin-3 levels and poor right ventricular (RV) function predict long-term mortality in heart failure (HF) patients receiving cardiac resynchronization therapy (CRT). Lack of CRT response further worsens survival in those with high galectin-3.

Area of Science:

  • Cardiology
  • Biomarkers
  • Heart Failure Research

Background:

  • Galectin-3 is associated with heart failure (HF) pathophysiology and right ventricular (RV) dysfunction.
  • Cardiac resynchronization therapy (CRT) is a treatment for HF, but long-term prognostic factors require further investigation.

Purpose of the Study:

  • To evaluate the long-term prognostic value of galectin-3 and RV function for all-cause mortality in HF patients undergoing CRT.
  • To identify predictors of survival in patients with reduced left ventricular ejection fraction (LVEF) treated with CRT.

Main Methods:

  • Prospective study of 63 symptomatic HF patients with LVEF ≤ 35% treated with CRT.
  • Measurement of serum galectin-3 levels and comprehensive echocardiographic assessment of RV and left ventricular (LV) function.
  • 5-year follow-up to determine all-cause mortality, analyzed using multivariable Cox regression.

Main Results:

  • Baseline galectin-3 concentration and RV function (tricuspid annular plane systolic excursion) were independent predictors of 5-year all-cause mortality.
  • High galectin-3 levels (HR 2.96) and impaired RV function (HR 0.88) were associated with increased mortality risk.
  • Patients with high galectin-3 and poor response to CRT exhibited significantly lower survival rates.

Conclusions:

  • Serum galectin-3 concentration and RV function are significant independent predictors of long-term mortality in heart failure with reduced ejection fraction (HFrEF) patients post-CRT.
  • Galectin-3 may help identify HFrEF patients at higher risk of mortality, especially those with suboptimal response to CRT.
  • These biomarkers offer potential for risk stratification and personalized treatment strategies in CRT recipients.

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