Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Geoid and Ellipsoid01:28

Geoid and Ellipsoid

192
The Earth's shape is best described as an ellipsoid, a slightly flattened sphere created by rotating an ellipse around its minor axis. This flattening results in the polar axis being about 21 kilometers shorter than the equatorial axis. In contrast, the geoid represents the Earth's gravitational shape and aligns with the mean sea level (MSL). The geoid is an irregular equipotential surface where gravity is perpendicular at every point. Variations in Earth's mass distribution cause geoid...
192
Gravitation Between Spherically Symmetric Masses01:14

Gravitation Between Spherically Symmetric Masses

1.0K
The gravitational potential energy between two spherically symmetric bodies can be calculated from the masses and the distance between the bodies, assuming that the center of mass is concentrated at the respective centers of the bodies.
1.0K
Spherical Coordinates01:23

Spherical Coordinates

11.8K
Spherical coordinate systems are preferred over Cartesian, polar, or cylindrical coordinates for systems with spherical symmetry. For example, to describe the surface of a sphere, Cartesian coordinates require all three coordinates. On the other hand, the spherical coordinate system requires only one parameter: the sphere's radius. As a result, the complicated mathematical calculations become simple. Spherical coordinates are used in science and engineering applications like electric and...
11.8K
Gauss's Law: Spherical Symmetry01:26

Gauss's Law: Spherical Symmetry

8.2K
A charge distribution has spherical symmetry if the density of charge depends only on the distance from a point in space and not on the direction. In other words, if the system is rotated, it doesn't look different. For instance, if a sphere of radius R is uniformly charged with charge density ρ0, then the distribution has spherical symmetry. On the other hand, if a sphere of radius R is charged so that the top half of the sphere has a uniform charge density ρ1 and the bottom half...
8.2K
Centroid for the Paraboloid of Revolution01:16

Centroid for the Paraboloid of Revolution

688
The paraboloid of revolution is an axially symmetric surface generated by rotating a parabola around its axis. This shape has several applications in mechanical engineering due to its advantageous structural properties, such as strength against stress concentration points and rotational symmetry.
The centroid for the paraboloid of revolution is the point where all the mass of the paraboloid is concentrated. This centroid is important for engineering applications, as it determines how forces are...
688

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Real-time, automated, standardized, and transparent analysis of microfluidic nanoparticle data with RPS<sub>PASS</sub>.

bioRxiv : the preprint server for biology·2026
Same author

Towards Accurate Breslow Measurements: Mitigating Issues in Histopathological Imaging.

Entropy (Basel, Switzerland)·2026
Same author

Benchmarking DNA barcode decoding strategies under high error rates.

BMC bioinformatics·2026
Same author

Real-world, multi-omics validation of the clinical relevance of molecular taxonomy for myelodysplastic syndromes (MDS).

HemaSphere·2026
Same author

Transferrin in combination with induction chemotherapy improves outcomes in mouse models of acute myeloid leukemia.

Science translational medicine·2026
Same author

A living biobank of sarcoma patient-derived cell cultures reveals multi-omic and functional insights that capture disease heterogeneity.

Clinical and translational medicine·2026

Related Experiment Video

Updated: Oct 14, 2025

High-throughput Image Analysis of Tumor Spheroids: A User-friendly Software Application to Measure the Size of Spheroids Automatically and Accurately
08:39

High-throughput Image Analysis of Tumor Spheroids: A User-friendly Software Application to Measure the Size of Spheroids Automatically and Accurately

Published on: July 8, 2014

25.5K

MISpheroID: a knowledgebase and transparency tool for minimum information in spheroid identity.

Arne Peirsman1,2,3, Eva Blondeel1,2, Tasdiq Ahmed4

  • 1Laboratory of Experimental Cancer Research, Cancer Research Institute, Ghent, Belgium.

Nature Methods
|November 2, 2021
PubMed
Summary
This summary is machine-generated.

Standardizing spheroid research is crucial for reproducibility. The MISpheroID Consortium created a knowledgebase and a reporting standard (MISpheroID string) to improve transparency and data interpretation for these 3D cell models.

More Related Videos

Affordable Oxygen Microscopy-Assisted Biofabrication of Multicellular Spheroids
13:21

Affordable Oxygen Microscopy-Assisted Biofabrication of Multicellular Spheroids

Published on: April 6, 2022

3.6K
A Robust Method for the Large-Scale Production of Spheroids for High-Content Screening and Analysis Applications
06:40

A Robust Method for the Large-Scale Production of Spheroids for High-Content Screening and Analysis Applications

Published on: December 28, 2021

3.6K

Related Experiment Videos

Last Updated: Oct 14, 2025

High-throughput Image Analysis of Tumor Spheroids: A User-friendly Software Application to Measure the Size of Spheroids Automatically and Accurately
08:39

High-throughput Image Analysis of Tumor Spheroids: A User-friendly Software Application to Measure the Size of Spheroids Automatically and Accurately

Published on: July 8, 2014

25.5K
Affordable Oxygen Microscopy-Assisted Biofabrication of Multicellular Spheroids
13:21

Affordable Oxygen Microscopy-Assisted Biofabrication of Multicellular Spheroids

Published on: April 6, 2022

3.6K
A Robust Method for the Large-Scale Production of Spheroids for High-Content Screening and Analysis Applications
06:40

A Robust Method for the Large-Scale Production of Spheroids for High-Content Screening and Analysis Applications

Published on: December 28, 2021

3.6K

Area of Science:

  • Cell biology
  • Biotechnology
  • 3D cell culture

Background:

  • Spheroids are vital 3D cell models in research and industry.
  • Lack of methodological standards hinders reproducibility in spheroid studies.

Purpose of the Study:

  • To address the lack of standardization in spheroid research.
  • To develop a resource and a reporting tool for spheroid experimental parameters.

Main Methods:

  • Assembled a crowdsourced knowledgebase of 3,058 published spheroid experiments.
  • Analyzed experimental parameters for heterogeneity.
  • Conducted empirical validation of methodological variations.

Main Results:

  • Identified significant heterogeneity in spheroid experimental setups.
  • Demonstrated diverse impacts of methodological variations on spheroid metrics.
  • Defined the MISpheroID string for minimum reporting parameters.

Conclusions:

  • The MISpheroID knowledgebase and string provide a valuable resource for 3D cell models.
  • These tools aim to improve transparency, interpretation, and reproducibility in spheroid research.