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DNA Mutations via Chern-Simons Currents.

Francesco Bajardi^1,2, Lucia Altucci^3,4, Rosaria Benedetti³

¹Dipartimento di Fisica "Ettore Pancini", Università degli Studi di Napoli"Federico II", Compl. Univ. di Monte S. Angelo, Edificio G, Via Cinthia, 80126 Napoli, Italy.

European Physical Journal Plus

|November 2, 2021

Summary

This summary is machine-generated.

This study applies Chern-Simons theory to DNA, revealing genomic string curvature correlates with genetic mutations in KRAS and COVID-19 sequences. Mutations occur at high current gradients, leading to smoother DNA structures.

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Area of Science:

* Theoretical physics
* Genomics
* Bioinformatics

Background:

* Topological field theories, such as Chern-Simons theory, are typically used in effective gravity.
* Understanding DNA structure and dynamics is crucial for genetic mutation research.

Purpose of the Study:

* To investigate the application of Chern-Simons theory to model DNA structure and dynamics.
* To correlate genomic string curvature with genetic mutations in human genes and viral sequences.
* To explore the utility of Chern-Simons currents in identifying mutation locations.

Main Methods:

* Utilized an analogue gravity approach based on Chern-Simons theory.
* Calculated the expectation value of the Wilson Loop to derive point-like curvature.
* Analyzed genomic sequences from the KRAS human gene and COVID-19.

Main Results:

* Identified a correlation between point-like curvature of genomic strings and genetic mutations.
* Demonstrated that mutations in KRAS and COVID-19 sequences are located at high Chern-Simons current gradients.
* Observed that mutated sequences exhibit smoother curvature compared to initial sequences.

Conclusions:

* The Chern-Simons theory provides a valid framework for schematizing DNA structure and dynamics.
* Point-like curvature analysis can effectively infer mutation positions within genetic strings.
* Mutation processes align with free energy minimization principles, resulting in smoother genomic structures.