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Related Concept Videos

Skin Cancer01:30

Skin Cancer

4.9K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Pigmentation01:19

Pigmentation

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The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
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Papillary Dermis01:11

Papillary Dermis

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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
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Related Experiment Video

Updated: Oct 14, 2025

A 3D Organotypic Melanoma Spheroid Skin Model
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A 3D Organotypic Melanoma Spheroid Skin Model

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Primary Dermal Melanoma: A Case Report.

Amy Weiss1, Rachel E Christensen1, Amin Maghari2

  • 1Department of Dermatology, Rutgers Robert Wood Johnson Medical School, Somerset, NJ; and.

The American Journal of Dermatopathology
|November 2, 2021
PubMed
Summary
This summary is machine-generated.

Primary dermal melanoma (PDM) is a rare skin cancer challenging to diagnose due to its similarity to metastatic melanoma. Accurate recognition and physician awareness are crucial for effective management and improved patient outcomes.

Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Primary dermal melanoma (PDM) presents diagnostic challenges due to histopathological overlap with cutaneous metastatic melanoma.

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  • Accurate diagnosis is complicated by the lack of established criteria for PDM staging and management.