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Superselective intra-arterial cerebral infusion to improve brain tumor drug delivery

Julian S Rechberger1,2, Charlotte A Hayes1,3, Frederic Thiele4

  • 1Department of Neurologic Surgery, Mayo Clinic, Rochester, MN 55905, USA.

Therapeutic Delivery
|November 2, 2021
PubMed

Abstract:

Graphical abstract [Formula: see text].

Keywords:
SIACIblood–brain barrierbrain tumorchemotherapydrug deliverygliomaimmunotherapyinfusionintra-arterialnanoparticlestargeted therapytreatment

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The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
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