Mimics and Chameleons in Guillain-Barré Syndrome

Guillain-Barré syndrome (GBS) is an immune-mediated disease of the peripheral nervous system that is triggered by both infectious processes and post-immunization conditions. It is, therefore, more prevalent during infectious outbreaks. While the classical clinical presentation of ascending paralysis is easy to recognize, GBS is a heterogeneous entity comprising several variants, atypical presentations, and incomplete forms that may make the diagnosis challenging. Early recognition is key because the disease could be rapidly fatal. Monitoring for progression of illness, fluctuations in vital signs, and prompt initiation of intravenous immunoglobulin are the mainstays of treatment.