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Author Spotlight: Developing Precise and Clinically Relevant Models for Studying Secondary Degeneration in Traumatic Optic Neuropathy
Published on: November 29, 2024
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Optic nerve infiltration in systemic non Hodgkin lymphoma
Cassie A Cameron1, Valerie Juniat1, Jessica Y Tong2
1Discipline of Ophthalmology and Visual Sciences, The University of Adelaide and the South Australian Institute of Ophthalmology, Adelaide, Australia.
Orbit (Amsterdam, Netherlands)
|November 3, 2021
Summary
Systemic non-Hodgkin lymphoma (NHL) rarely infiltrates the optic nerve, presenting as optic neuropathy. Early consideration of this rare diagnosis is crucial for timely intervention.
Area of Science:
- Ophthalmology
- Neurology
- Hematology
Background:
- Optic nerve infiltration by systemic non-Hodgkin lymphoma (NHL) is uncommon.
- Presents as isolated optic neuropathy with non-specific neurological symptoms.
Approach:
- Literature review of systemic NHL with optic nerve infiltration.
- Analysis of magnetic resonance imaging (MRI) findings.
- Discussion of diagnostic challenges and yields.
Key Points:
- MRI shows characteristic optic nerve enhancement and enlargement.
- Leptomeningeal enhancement is infrequent.
- Cerebrospinal fluid analysis and optic nerve sheath biopsy may yield false negatives.
Conclusions:
- Biopsy of optic nerve substance offers high diagnostic yield when other tests are inconclusive.
- Lymphomatous optic nerve infiltration should be considered in differential diagnosis of pale, swollen optic disc.
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