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Updated: Oct 14, 2025

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
Published on: November 1, 2015
TNF-induced Lupus. A Case-Based Review.
Anastasia Skalkou1, Eleftherios Pelechas1, Paraskevi V Voulgari1
1Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, Ioannina 45110, Greece.
Tumor necrosis factor-alpha (TNFα) inhibitors effectively treat inflammatory arthritis but can rarely cause drug-induced lupus (DIL). Rheumatologists must monitor patients for autoimmune side effects like DIL during TNFα inhibitor therapy.
Area of Science:
- Immunology
- Rheumatology
- Dermatology
Background:
- Tumor necrosis factor-alpha (TNFα) inhibitors are effective treatments for inflammatory arthropathies.
- While generally safe, TNFα inhibitors have been associated with autoimmune phenomena, including drug-induced lupus (DIL).
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