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A medullary centre for lapping in mice.

Bowen Dempsey1, Selvee Sungeelee1, Phillip Bokiniec2

  • 1Institut de Biologie de l'ENS (IBENS), Inserm, CNRS, École normale supérieure, PSL Research University, Paris, France.

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This summary is machine-generated.

Researchers identified two brainstem nuclei, IRtPhox2b and Peri5Atoh1, that organize fluid ingestion movements in mice. These nuclei control jaw and tongue muscles, with IRtPhox2b specifically orchestrating rhythmic lapping motions.

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Area of Science:

  • Neuroscience
  • Motor Control
  • Feeding Behavior

Background:

  • Orofacial movements for feeding are coordinated by the brainstem.
  • Subcortical control of ingestive behaviors is not fully understood.

Purpose of the Study:

  • Identify brainstem nuclei organizing fluid ingestion.
  • Investigate the role of specific neuronal groups in feeding movements.

Main Methods:

  • Neuronal stimulation in awake mice.
  • Fiber photometry for neural activity recording.
  • Identification of Phox2b-expressing neuronal groups.

Main Results:

  • Two nuclei, IRtPhox2b and Peri5Atoh1, were identified as key organizers of fluid ingestion.
  • Stimulation of these nuclei elicited jaw opening and tongue protraction.
  • IRtPhox2b stimulation induced rhythmic lapping movements, and was active during volitional lapping.

Conclusions:

  • IRtPhox2b and Peri5Atoh1 are critical subcortical centers for organizing feeding behaviors.
  • This study reveals novel neural circuits underlying stereotyped ingestive actions.