Fluoroquinolone antibiotics and adverse events

Area of Science:

• Pharmacology and Infectious Diseases

Background:

• Fluoroquinolones are broad-spectrum antibiotics with excellent oral absorption.
• Their use is widespread but subject to prescribing restrictions due to potential adverse events.

Purpose of the Study:

• To highlight the risks associated with fluoroquinolone use.
• To emphasize the importance of safe prescribing practices and antimicrobial stewardship.

Main Methods:

• Review of epidemiological studies on fluoroquinolone adverse effects.
• Analysis of risk factors and management strategies for fluoroquinolone toxicity.

Main Results:

• Epidemiological data indicate an increased risk of rare but serious adverse effects.
• These include tendinopathy, tendon rupture, peripheral neuropathy, and aortic aneurysm.
• Identification of patient risk factors for toxicity is essential.

Conclusions:

• Safe fluoroquinolone prescribing necessitates recognizing at-risk patients and prompt discontinuation upon adverse reactions.
• Antimicrobial stewardship, including reserving fluoroquinolones for situations where alternatives are unsuitable, is vital to minimize harm and resistance.