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Published on: July 25, 2022
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Nanoparticle approaches against SARS-CoV-2 infection.
Yaou Duan1, Shuyan Wang1, Qiangzhe Zhang1
1Department of NanoEngineering, Chemical Engineering Program, Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA.
Current Opinion in Solid State & Materials Science
|November 3, 2021
Summary
Nanoparticles offer advanced strategies for detecting, treating, and vaccinating against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). These tailor-made materials enhance the response to the COVID-19 pandemic and future viral threats.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Infectious Diseases
Background:
- Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, represents a significant global health crisis.
- Conventional therapeutic approaches have limitations in combating viral pandemics.
- Nanoparticles present novel opportunities for antiviral interventions.
Purpose of the Study:
- To review nanoparticle-based strategies for COVID-19 detection, treatment, and vaccination.
- To discuss the structure-function relationships of various nanoparticles against SARS-CoV-2.
- To highlight the potential of nanoparticles in pandemic preparedness.
Main Methods:
- Review of existing literature on nanoparticle applications for COVID-19.
- Categorization of strategies into detection, treatment, and vaccines.
- Analysis of nanoparticle design and biointerfacing capabilities.
Main Results:
- Diverse nanoparticle types (inorganic, lipid, polymeric, virus-like, cell membrane-coated) show promise.
- Nanoparticles facilitate tailored biointerfacing with host and virus for enhanced efficacy.
- Specific nanoparticle designs demonstrate effective antiviral activity.
Conclusions:
- Nanoparticles provide versatile platforms for combating SARS-CoV-2.
- These advanced materials significantly improve current COVID-19 response.
- Nanotechnology enhances preparedness for future viral outbreaks.
