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Multimodality imaging in patients with heart failure and preserved ejection fraction: an expert consensus document of
Otto A Smiseth1,2,3, Daniel A Morris4, Nuno Cardim5
1Department of Cardiology, Oslo University Hospital, Rikshospitalet, Sognsvannsveien 20, Oslo, Norway.
Insights
Heart failure with preserved ejection fraction (HFpEF) affects many patients and has poor prognosis. This expert document offers imaging guidance to identify causes and improve treatment for HFpEF.
Area of Science:
- Cardiology
- Medical Imaging
Background:
- Heart failure with preserved ejection fraction (HFpEF) accounts for nearly half of all heart failure (HF) cases.
- HFpEF is associated with a prognosis nearly as severe as heart failure with reduced ejection fraction (HFrEF).
- Limited therapeutic options with proven prognostic benefits exist for HFpEF, unlike HFrEF.
Purpose of the Study:
- To provide recommendations for diagnosing elevated left ventricular (LV) filling pressures in suspected HFpEF.
- To guide the use of multimodality imaging for identifying specific etiologies in HFpEF patients.
Main Methods:
- Expert consensus document from the European Association of Cardiovascular Imaging (EACVI).
- Focus on multimodality imaging techniques.
- Development of diagnostic criteria for elevated LV filling pressure.
Main Results:
- HFpEF is a heterogeneous condition with diverse underlying pathologies.
- Multimodality imaging can differentiate these pathologies.
- Standardized diagnostic criteria are needed for HFpEF.
Conclusions:
- Accurate diagnosis of HFpEF requires assessment of LV filling pressures.
- Multimodality imaging is crucial for determining specific causes of HFpEF.
- Improved diagnostic approaches may facilitate therapeutic development for HFpEF.
Abstract:
Nearly half of all patients with heart failure (HF) have a normal left ventricular (LV) ejection fraction (EF) and the condition is termed heart failure with preserved ejection fraction (HFpEF). It is assumed that in these patients HF is due primarily to LV diastolic dysfunction. The prognosis in HFpEF is almost as severe as in HF with reduced EF (HFrEF). In contrast to HFrEF where drugs and devices are proven to reduce mortality, in HFpEF there has been limited therapy available with documented effects on prognosis. This may reflect that HFpEF encompasses a wide range of different pathological processes, which multimodality imaging is well placed to differentiate. Progress in developing therapies for HFpEF has been hampered by a lack of uniform diagnostic criteria. The present expert consensus document from the European Association of Cardiovascular Imaging (EACVI) provides recommendations regarding how to determine elevated LV filling pressure in the setting of suspected HFpEF and how to use multimodality imaging to determine specific aetiologies in patients with HFpEF.
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