Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Oct 14, 2025

Quantification of Strain in a Porcine Model of Skin Expansion Using Multi-View Stereo and Isogeometric Kinematics
14:14

Quantification of Strain in a Porcine Model of Skin Expansion Using Multi-View Stereo and Isogeometric Kinematics

Published on: April 16, 2017

11.7K

Multiscale Computational Model Predicts Mouse Skin Kinematics Under Tensile Loading.

Nathan J Witt1, Alan E Woessner2, Kyle P Quinn2

  • 1Roy J. Carver Department of Biomedical Engineering, College of Engineering, University of Iowa, Iowa City, IA 52242.

Journal of Biomechanical Engineering
|November 3, 2021
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Autofluorescence lifetime of gelatin-methacrylate hydrogels is sensitive to changes in crosslinking and post-gelation pH.

Frontiers in bioengineering and biotechnology·2026
Same author

<i>In Vivo</i>, Label-Free Multiphoton Microscopy Is Sensitive to Altered Metabolism and Structure in Aged Skin.

Advances in wound care·2026
Same author

Aroclor 1254 inhibits anti-inflammatory macrophage polarization through an AhR-dependent mechanism.

Journal of the Endocrine Society·2026
Same author

Characterizing the role of mitochondrial dynamics during <i>Drosophila</i> convergent extension using NADH fluorescence lifetime imaging.

bioRxiv : the preprint server for biology·2026
Same author

Consensus guidelines for cellular label-free optical metabolic imaging: ensuring accuracy and reproducibility in metabolic profiling.

Journal of biomedical optics·2025
Same author

The 2025 Young Innovators of Cellular and Molecular Bioengineering.

Cellular and molecular bioengineering·2025

Multiscale mechanical models reveal that mouse skin

Area of Science:

  • Biomechanics
  • Materials Science
  • Dermatology

Background:

  • Traditional models assume skin is incompressible.
  • Recent experiments show skin has a high Poisson's ratio and non-affine fiber deformation.
  • Understanding these properties requires advanced modeling.

Purpose of the Study:

  • To develop multiscale mechanical models (MSM) of mouse skin.
  • To investigate the biomechanical basis for skin's observed properties under uniaxial tension.
  • To compare model predictions with experimental data.

Main Methods:

  • Constructed MSMs of mouse skin using multiphoton microscopy.
  • Imaged dermal microstructure during mechanical testing.
  • Developed models for aligned, moderately aligned, and random fiber networks.
Keywords:
biomechanicscollagendermisfiber networksmultiphoton microscopynonaffine

More Related Videos

Author Spotlight: PEGASOS Tissue Clearing Technique to Visualize Bone Remodeling
06:51

Author Spotlight: PEGASOS Tissue Clearing Technique to Visualize Bone Remodeling

Published on: August 18, 2023

1.7K
Biomechanical Testing of Murine Tendons
10:09

Biomechanical Testing of Murine Tendons

Published on: October 15, 2019

13.7K

Related Experiment Videos

Last Updated: Oct 14, 2025

Quantification of Strain in a Porcine Model of Skin Expansion Using Multi-View Stereo and Isogeometric Kinematics
14:14

Quantification of Strain in a Porcine Model of Skin Expansion Using Multi-View Stereo and Isogeometric Kinematics

Published on: April 16, 2017

11.7K
Author Spotlight: PEGASOS Tissue Clearing Technique to Visualize Bone Remodeling
06:51

Author Spotlight: PEGASOS Tissue Clearing Technique to Visualize Bone Remodeling

Published on: August 18, 2023

1.7K
Biomechanical Testing of Murine Tendons
10:09

Biomechanical Testing of Murine Tendons

Published on: October 15, 2019

13.7K

Main Results:

  • MSMs accurately predicted mouse skin's biomechanical behavior.
  • Models captured the significant volume decrease during uniaxial loading.
  • Non-affine collagen fiber kinematics were successfully replicated.

Conclusions:

  • Multiscale mechanical models can predict complex skin biomechanics.
  • Fiber organization significantly influences skin's mechanical response.
  • MSMs provide a framework for understanding skin tissue mechanics.