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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Peptic Ulcer Disease I: Introduction01:30

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Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
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Factors Affecting the Risk of Infection01:26

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The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
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Updated: Oct 14, 2025

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid
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Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid

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Comorbid diseases associated with pemphigus: a case-control study.

Federico Bardazzi1, Paola Rucci2, Simona Rosa2

  • 1Department of Experimental, Diagnostic and Specialty Medicine - Dermatology - IRCCS Policlinico di Sant'Orsola, Bologna, Italy.

Journal Der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
|November 3, 2021
PubMed
Summary
This summary is machine-generated.

Cancer and other autoimmune conditions may trigger pemphigus (a rare autoimmune blistering disease). Early detection of these comorbidities can serve as warning signs for pemphigus development.

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Area of Science:

  • Dermatology
  • Autoimmune Diseases
  • Oncology

Background:

  • Pemphigus is linked to various physical and psychiatric comorbidities.
  • Understanding these associations is crucial for comprehensive patient care.

Purpose of the Study:

  • To investigate comorbidities in pemphigus patients.
  • To analyze associations with patient demographics, disease severity, and involvement.

Main Methods:

  • 163 pemphigus patients were matched with controls.
  • Conditional logistic regression models analyzed comorbid conditions.
  • Multivariable analysis identified independent associations.

Main Results:

  • Cardiovascular diseases, hyperlipidemia, autoimmune thyroid disorders, dermatological autoimmune/inflammatory conditions, and cancer were prominent.
  • Cancer and dermatological autoimmune/inflammatory conditions were independently associated with pemphigus.
  • Associations remained significant after excluding paraneoplastic pemphigus cases.

Conclusions:

  • Cancer and dermatological autoimmune/inflammatory conditions may trigger pemphigus.
  • These comorbidities could serve as early warning signs for pemphigus.