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Related Experiment Video

Updated: Oct 14, 2025

Plasmonic Photothermal Cancer Therapy: Nanoparticle-embedded Tumor-tissue-mimicking Phantoms for Visualizing Photothermal Temperature Distribution
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Thrombin Based Photothermal-Responsive Nanoplatform for Tumor-Specific Embolization Therapy.

Jiajia Yin1, Xiaorui Wang1, Xu Sun1

  • 1Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), School of Physical and Mathematical Sciences, Nanjing Tech University (NanjingTech), Nanjing, 211816, China.

Small (Weinheim an Der Bergstrasse, Germany)
|November 3, 2021
PubMed
Summary

This study presents a novel photothermal therapy for solid tumors using phase-change material (PCM) nanoparticles to deliver thrombin (Thr). This approach enables safe, targeted embolization of tumor vasculature, offering a promising cancer treatment strategy.

Keywords:
blood coagulationembolization therapyintravenous injectionphase-change materialsthrombin

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Oncology

Background:

  • Tumor-specific embolization therapy aims to ablate solid tumors by inducing coagulation in tumor vasculature.
  • Challenges exist in the safe and effective delivery of vessel occluding agents for tumor embolization.

Purpose of the Study:

  • To develop a photothermal-responsive, tumor-specific embolization therapy using phase-change material (PCM)-based nanoparticles for delivering thrombin (Thr).
  • To ensure safe delivery and controlled release of Thr at the tumor site for effective vascular occlusion.

Main Methods:

  • Intravenous injection of PCM-based nanoparticles loaded with thrombin (Thr).
  • Utilizing the photothermal effect induced by IR780 at the tumor site to trigger PCM melting and Thr release.
  • Monitoring coagulation in tumor blood vessels and assessing therapeutic efficacy and safety.

Main Results:

  • PCM nanoparticles enabled safe, systemic delivery of Thr, preventing premature release in circulation.
  • Photothermal stimulation at the tumor site led to rapid PCM melting and localized Thr release.
  • Effective induction of coagulation in tumor vasculature, leading to vascular infarction with no significant damage to normal tissues.

Conclusions:

  • The developed photothermal-responsive embolization therapy offers a safe and efficient strategy for tumor ablation.
  • PCM-based nanoparticles facilitate controlled release of Thr, enhancing therapeutic specificity and efficacy.
  • This approach shows significant promise for improving coagulation-based cancer therapies.