Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

G Protein-coupled Receptors01:15

G Protein-coupled Receptors

14.0K
G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
14.0K
GPCRs Regulate Adenylyl Cylase Activity01:09

GPCRs Regulate Adenylyl Cylase Activity

6.1K
Some GPCRs transmit signals through adenylyl cyclase (AC), a transmembrane enzyme. AC helps synthesize second messenger cyclic adenosine monophosphate (cAMP). AC catalyzes cyclization reaction and converts ATP to cAMP by releasing a pyrophosphate. The pyrophosphate is further hydrolyzed to phosphate by the enzyme pyrophosphatase, which drives cAMP synthesis to completion. However, cAMP is rapidly degraded to 5′ AMP by the enzymes phosphodiesterase (PDE), preventing overstimulation of...
6.1K
Transducer Mechanism: G Protein–Coupled Receptors01:30

Transducer Mechanism: G Protein–Coupled Receptors

2.9K
G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
GPCRs are also called heptahelical,...
2.9K
Adhesion01:14

Adhesion

42.0K
Adhesion occurs when one type of molecule is attracted to a different molecule. Water exhibits adhesive properties in the presence of polar surfaces, such as glass or cellulose in plants. For instance, when water is poured into a glass, the positively charged hydrogen molecules of water are more attracted to the negatively charged oxygen molecules in the silica than to the oxygen in neighboring water molecules.
Capillary action is a result of water’s adhesive tendencies. When a narrow...
42.0K
GPCR Desensitization01:12

GPCR Desensitization

6.7K
G protein-coupled receptor (GPCR) signaling plays a crucial role in cell functioning. GPCR desensitization is an equally essential process. It allows cells to respond to changing environments and regain sensitivity to new stimuli while preventing unnecessary stimulation when no longer needed. Prolonged exposure to stimuli leads to GPCR desensitization. It involves blocking the receptors from binding and activating additional G proteins. This inhibits activation of downstream effectors, thereby...
6.7K
G-protein Coupled Receptors01:21

G-protein Coupled Receptors

124.5K
G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
124.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

GPR3 Ligands Discovered through Combined Virtual and Conformational Biosensor-Based Screening.

Journal of the American Chemical Society·2026
Same author

Selective Postsynthetic Reduction of Pyridinium Hydrazone Cages.

Organic letters·2026
Same author

Automated FRET Analysis for Enhanced Characterization of Protein-Protein Interactions.

Microscopy research and technique·2026
Same author

Adhesion G protein-coupled receptors.

Pharmacological reviews·2026
Same author

Protocol for isolating viable human central nervous system T cells.

STAR protocols·2026
Same author

Contact-dependent regulation of UV-B/C-induced cell fate by neighboring intact cells.

Journal of photochemistry and photobiology. B, Biology·2026
Same journal

A lipid-sensitive food choice behavior influences aging outcomes from a longevity-promoting diet.

The FEBS journal·2026
Same journal

The interaction network of a rice seed-specific transcription factor OsMADS29 and the calcium sensors, calmodulin, and calmodulin-like proteins.

The FEBS journal·2026
Same journal

A large family of unusual voltage-sensing proton channels (Hv3) in mollusks.

The FEBS journal·2026
Same journal

RVB-1 and RVB-2 are stress responsive proteins in Neurospora crassa and RVB-1 interacts with the centromeric Shugoshin (SGO-1) protein.

The FEBS journal·2026
Same journal

Human APOBEC3G suppresses homologous recombination and LIG4-independent end joining in DNA double-strand break repair.

The FEBS journal·2026
Same journal

Nephronophthisis: Current clinical spectrum and molecular pathogenesis.

The FEBS journal·2026
See all related articles

Related Experiment Video

Updated: Oct 14, 2025

Monitoring GPCR-β-arrestin1/2 Interactions in Real Time Living Systems to Accelerate Drug Discovery
08:21

Monitoring GPCR-β-arrestin1/2 Interactions in Real Time Living Systems to Accelerate Drug Discovery

Published on: June 28, 2019

7.0K

A guide to adhesion GPCR research.

Ines Liebscher1, Orkun Cevheroğlu2, Cheng-Chih Hsiao3

  • 1Division of Molecular Biochemistry, Medical Faculty, Rudolf Schönheimer Institute of Biochemistry, Leipzig University, Germany.

The FEBS Journal
|November 3, 2021
PubMed
Summary
This summary is machine-generated.

Adhesion G protein-coupled receptors (aGPCRs) are crucial cell surface receptors with significant health implications and untapped therapeutic potential. This review synthesizes current knowledge and future strategies for advancing aGPCR research from basic science to clinical applications.

Keywords:
Adhesion GPCRsclinical applicationphysiologysignalingstructure-function

More Related Videos

Genetically-encoded Molecular Probes to Study G Protein-coupled Receptors
16:16

Genetically-encoded Molecular Probes to Study G Protein-coupled Receptors

Published on: September 13, 2013

15.4K
Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules
08:15

Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules

Published on: October 17, 2014

10.7K

Related Experiment Videos

Last Updated: Oct 14, 2025

Monitoring GPCR-β-arrestin1/2 Interactions in Real Time Living Systems to Accelerate Drug Discovery
08:21

Monitoring GPCR-β-arrestin1/2 Interactions in Real Time Living Systems to Accelerate Drug Discovery

Published on: June 28, 2019

7.0K
Genetically-encoded Molecular Probes to Study G Protein-coupled Receptors
16:16

Genetically-encoded Molecular Probes to Study G Protein-coupled Receptors

Published on: September 13, 2013

15.4K
Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules
08:15

Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules

Published on: October 17, 2014

10.7K

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pharmacology

Background:

  • Adhesion G protein-coupled receptors (aGPCRs) are vital cell surface proteins with complex roles in health and disease.
  • Their unique structure and function present significant, yet largely unexplored, pharmacological opportunities.

Purpose of the Study:

  • To review the current understanding of aGPCRs, focusing on structure-function relationships, physiology, and clinical relevance.
  • To identify key challenges and propose strategies for advancing aGPCR research.
  • To explore pathways for translating aGPCR discoveries from the laboratory to clinical practice.

Main Methods:

  • Comprehensive literature review of recent advancements in aGPCR research.
  • Synthesis of knowledge on aGPCR structure, signaling, and physiological roles.
  • Analysis of current methodologies and tools for studying aGPCRs.

Main Results:

  • aGPCRs possess significant, unexploited pharmacological potential.
  • Integrating diverse research approaches is crucial for in-depth understanding.
  • Translational strategies are needed to bridge basic research and clinical application.

Conclusions:

  • Further research into aGPCRs is essential for understanding their roles in health and disease.
  • Novel tools and interdisciplinary approaches will accelerate progress in the field.
  • Translating aGPCR research 'from bench to bedside' holds promise for future therapeutics.