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In vitro activity of imipenem against gram-positive anaerobic bacteria
Abstract:
The in vitro activity of imipenem, a new penem antibiotic, was determined against 210 clinical Gram-positive anaerobic isolates and compared with the activities of metronidazole, clindamycin, cefoxitin, moxalactam, ceftizoxime, ceftriaxone and cefotiam. All investigated strains were inhibited by a 4-mg/l concentration of imipenem. Cefoxitin demonstrated good activity against most strains with exception of some Clostridium difficile and Clostridium ramosum strains. Cephalosporins were classed in decreasing activity order as follows: cefoxitin moxalactam ceftriaxone ceftizoxime cefotiam. Metronidazole had better activity against Clostridium spp. than against non-sporulated bacilli. Clindamycin resistance rates were superior to 10% for most groups, with the exception of Clostridium perfringens. Actinomyces and Bifidobacterium. Imipenem was the most potent inhibitor, as 81% and 95% of tested strains were inhibited at concentrations of 0.25 and 0.5 mg/l respectively.
Insights
Imipenem shows potent in vitro activity against Gram-positive anaerobic bacteria, inhibiting all tested strains. This new penem antibiotic is a promising option for treating anaerobic infections.
Area of Science:
- Microbiology
- Infectious Diseases
- Pharmacology
Background:
- Anaerobic Gram-positive bacteria are significant pathogens.
- Evaluating new antibiotics against these organisms is crucial for effective treatment.
Purpose of the Study:
- To assess the in vitro activity of imipenem against clinical isolates of Gram-positive anaerobic bacteria.
- To compare imipenem's efficacy with existing antibiotics like metronidazole and cephalosporins.
Main Methods:
- In vitro susceptibility testing of 210 clinical Gram-positive anaerobic isolates.
- Determination of minimum inhibitory concentrations (MICs) for imipenem and comparator agents.
Main Results:
- Imipenem demonstrated potent activity, inhibiting all strains at 4 mg/l.
- 81% and 95% of strains were inhibited by 0.25 and 0.5 mg/l imipenem, respectively.
- Cephalosporins showed varying activity, with cefoxitin being most effective, while clindamycin resistance exceeded 10% in most groups.
Conclusions:
- Imipenem exhibits superior in vitro activity against Gram-positive anaerobic bacteria compared to other tested agents.
- Imipenem represents a potent therapeutic option for infections caused by these resistant pathogens.