Related Experiment Video
Updated: Oct 14, 2025
04:39
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
2.0K
Hypothyroidism in vasculitis
Tanaz A Kermani1, David Cuthbertson2, Simon Carette3
1Division of Rheumatology, University of California, Los Angeles, Los Angeles, CA.
Rheumatology (Oxford, England)
|November 3, 2021
Summary
This study found hypothyroidism is more common in ANCA-associated vasculitis (AAV) and linked to MPO-ANCA. Clinical features were similar, except transient ischemic attacks in GCA patients with hypothyroidism.
Area of Science:
- Rheumatology and Endocrinology
- Autoimmune diseases
- Thyroid disorders
Background:
- Hypothyroidism is a common endocrine disorder.
- Vasculitis encompasses a group of autoimmune diseases characterized by inflammation of blood vessels.
- The relationship between hypothyroidism and various forms of vasculitis requires further investigation.
Purpose of the Study:
- To determine the prevalence of hypothyroidism across different types of vasculitis.
- To assess the risk factors associated with hypothyroidism in vasculitis patients.
- To explore clinical associations of hypothyroidism within vasculitis cohorts.
Main Methods:
- Prospective, multicenter, longitudinal study including patients with Giant Cell Arteritis (GCA), Takayasu's Arteritis (TAK), Polyarteritis Nodosa (PAN), and ANCA-associated Vasculitis (AAV) subtypes.
- Data collected on 2085 patients, analyzing hypothyroidism prevalence and risk adjusted for age and sex.
- Specific analysis for AAV patients with MPO-ANCA positivity.
Main Results:
- Hypothyroidism was present in 10% of the 2085 patients.
- Increased risk of hypothyroidism observed in Granulomatosis with Polyangiitis (GPA) and Microscopic Polyangiitis.
- Positive MPO-ANCA was associated with a higher risk of hypothyroidism in AAV patients. Transient ischemic attacks were more frequent in GCA patients with hypothyroidism.
Conclusions:
- The varying risk of hypothyroidism among vasculitides may stem from genetic predispositions or immune responses.
- This study confirms a significant association between hypothyroidism and MPO-ANCA.
- Further research into the underlying mechanisms connecting hypothyroidism and vasculitis is warranted.
Related Concept Videos
01:29Autoimmune Disorders
834
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
834
01:14Myocarditis III: Medical Management
31
Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
31
01:21Myocarditis I: Introduction
63
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
63
01:23The Thyroid Gland
4.7K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
4.7K
01:22Myocarditis IV: Nursing Management
58
Myocarditis is an inflammatory condition of the myocardium requiring meticulous nursing management for optimal patient outcomes. Effective management begins with a thorough assessment of the patient's medical history, paying close attention to past infections, autoimmune disorders, travel history, and exposure to toxins or drugs. Recent viral infections and systemic diseases are particularly relevant due to their potential role in triggering myocarditis.Physical Examination and MonitoringThe...
58
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
118
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
118