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COVID-19 prevalence and mortality in people with epilepsy: A nation-wide multicenter study

Alvaro Sanchez-Larsen1, Estefanía Conde-Blanco2, Alejandro Viloria-Alebesque3

  • 1Department of Neurology, Albacete University Hospital Complex, Albacete, Spain.

Epilepsy & Behavior : E&B
|November 3, 2021
PubMed

Insights

COVID-19 was moderately prevalent in people with epilepsy (PWE), with higher hospitalization and mortality rates compared to the general population. However, seizure control remained stable for most PWE during and after infection.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Epidemiology

Background:

  • Assessing the impact of COVID-19 on people with epilepsy (PWE) is crucial.
  • Understanding COVID-19 prevalence, severity, and mortality in PWE is essential.
  • Evaluating seizure control in PWE during and after COVID-19 infection is a key concern.

Purpose of the Study:

  • To determine the prevalence, severity, and mortality of COVID-19 in people with epilepsy (PWE).
  • To evaluate seizure control in PWE during and after COVID-19 infection.

Main Methods:

  • A retrospective, observational, multicenter study was conducted across 14 hospitals.
  • Medical records of randomly selected PWE from neurology outpatient clinics were reviewed.
  • COVID-19 prevalence, risk factors, and morbimortality in PWE were analyzed.

Main Results:

  • COVID-19 prevalence in PWE was 5.53%, higher than the Spanish population (4.26%).
  • PWE experienced higher rates of hospitalization (17.1% vs 10.81%), ICU admission (2% vs 0.95%), and death (4.61% vs 2.57%) from COVID-19.
  • Older age, dyslipidemia, institutionalization, and intellectual disability were risk factors for severe COVID-19 and mortality. Seizure control remained stable in 90.1% during acute infection, with 8.6% reporting increased seizures.

Conclusions:

  • COVID-19 is moderately prevalent in PWE, with increased risks of severe disease and death.
  • Risk factors for severe COVID-19 and mortality in PWE include older age, dyslipidemia, institutionalization, and intellectual disability.
  • Seizure control generally remained stable in PWE during and after COVID-19 infection, despite increased risks.
Abstract

Keywords:
COVID-19Coronavirus, SARS-CoV-2EpilepsyPrevalenceSeizures

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