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Telmisartan Exerts Cytotoxicity in Scirrhous Gastric Cancer Cells by Inducing G0/G1 Cell Cycle Arrest

Yoshie Tsujiya1, Motohiro Yamamori1, A I Hasegawa1

  • 1Department of Clinical Pharmacy, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya, Japan.

Anticancer Research
|November 4, 2021
PubMed
Abstract

Insights

Telmisartan (TEL) inhibits scirrhous gastric cancer (SGC) cell proliferation by inducing apoptosis and autophagy. This potential antitumor agent also causes G0/G1 cell cycle arrest, suggesting its promise for SGC treatment.

Area of Science:

  • Oncology
  • Pharmacology
  • Molecular Biology

Background:

  • Scirrhous gastric cancer (SGC) presents unique challenges in treatment.
  • Telmisartan (TEL), an angiotensin receptor blocker, has shown potential as an antitumor agent.
  • Understanding TEL's mechanism in SGC is crucial for therapeutic development.

Purpose of the Study:

  • To evaluate the effects of telmisartan (TEL) on scirrhous gastric cancer (SGC) cells.
  • To investigate TEL's mechanism of action, focusing on apoptosis, autophagy, and cell cycle regulation.
  • To assess TEL's potential as a therapeutic agent for SGC.

Main Methods:

  • Cell viability and chromatin condensation were assessed in SGC cell lines (OCUM-2M, OCUM-12).
  • Western blotting was used to analyze protein expression.
  • Flow cytometry was employed to determine cell cycle distribution and apoptosis.

Main Results:

  • Telmisartan (TEL) inhibited SGC cell proliferation in a dose-dependent manner.
  • TEL treatment increased chromatin condensation and the autophagy marker LC3-II in OCUM-12 cells.
  • TEL induced a significant increase in cells within the G0/G1 phase, indicating cell cycle arrest.

Conclusions:

  • Telmisartan (TEL) exhibits antitumor effects in scirrhous gastric cancer (SGC) through partial induction of apoptosis and autophagy.
  • TEL effectively causes G0/G1 cell cycle arrest in SGC cells.
  • Telmisartan (TEL) represents a promising therapeutic candidate for scirrhous gastric cancer treatment.
Keywords:
Telmisartanangiotensin II receptor blockerapoptosiscell cycle arrestscirrhous gastric cancer

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