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Pre-pectoral Breast Reconstruction Does Not Affect Early Immunological Response: A BIAL 2.20 Study Subanalysis
Gianluca Vanni1, Marco Pellicciaro2, Amir Sadri3
1Breast Unit, Department of Surgical Science, Policlinico Tor Vergata University, Rome, Italy.
Anticancer Research
|November 4, 2021
Summary
Direct-to-implant pre-pectoral (PP) breast reconstruction using titanium-coated mesh shows no increased immunological impairment compared to subpectoral (SP) reconstruction. PP reconstruction offers reduced operative time, blood loss, anemia, and lower postoperative pain.
Area of Science:
- Oncology
- Immunology
- Plastic Surgery
Background:
- Minimizing postoperative stress is crucial in surgical oncology to reduce lymphopenia.
- Evaluating immune response after direct-to-implant breast reconstruction is essential.
Purpose of the Study:
- To compare the early postoperative immune response between pre-pectoral (PP) and subpectoral (SP) breast reconstruction.
- To assess immunological impairment, pain, operative time, and anemia rates.
Main Methods:
- Prospective randomized study of 37 patients undergoing PP or SP breast reconstruction.
- Collected data on immune cell subsets, pain scores (NPRS), and blood counts on postoperative days 1 and 2.
- Utilized two-way analysis of variance for data evaluation.
Main Results:
- No significant difference in leukocytes or lymphocyte subsets between PP and SP groups.
- PP reconstruction demonstrated shorter operative times (mean difference 30.19 min).
- PP group showed significantly lower blood loss (p=0.017), reduced anemia (p=0.039), and less postoperative pain (p<0.001).
Conclusions:
- Pre-pectoral (PP) breast reconstruction with titanium-coated mesh does not worsen early postoperative immunological impairment compared to subpectoral (SP) reconstruction.
- PP reconstruction is associated with improved clinical outcomes, including reduced operative time, anemia, and pain.
