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High-Resolution Anorectal Manometry-A Prospective Cohort Study in Healthy Infants

Cathrine Gatzinsky1, Staffan Redfors2, Helena Borg1

  • 1Department of Pediatric Surgery.

Journal of Pediatric Gastroenterology and Nutrition
|November 4, 2021
PubMed

Insights

High-resolution anorectal manometry (HRAM) is safe and effective for diagnosing functional gastrointestinal disorders (FGD) in infants. This study provides crucial normative HRAM data for healthy infants at two and six months old.

Area of Science:

  • Pediatric Gastroenterology
  • Diagnostic Technology
  • Infant Health

Background:

  • Functional gastrointestinal disorders (FGD) are prevalent in early childhood.
  • Anorectal manometry (AM) is used to diagnose severe defecation disorders, but normative data for high-resolution anorectal manometry (HRAM) in infants is limited.
  • HRAM may enhance diagnostic accuracy for infant FGD.

Purpose of the Study:

  • To establish normative high-resolution anorectal manometry (HRAM) data in healthy infants at 2 and 6 months of age.
  • To compare HRAM findings in infants with and without functional gastrointestinal disorders (FGD), including functional constipation (FC), infant colic (IC), and infant dyschezia (ID).

Main Methods:

  • A prospective observational cohort study involving 107 healthy term infants.
  • High-resolution anorectal manometry (HRAM) was performed at 2 and 6 months using a water-perfused catheter.
  • Infant FGD (FC, IC, ID) was identified via questionnaires based on ROME 3 criteria.

Main Results:

  • 187 HRAM investigations were completed without complications.
  • A normal rectoanal inhibitory reflex (RAIR) was present in all infants.
  • Mean anal resting pressure (ARP) increased between 2 and 6 months in infants without FGD; no significant HRAM differences were observed between infants with or without FGD.

Conclusions:

  • This study provides normative HRAM data for infants at 2 and 6 months.
  • HRAM is a safe, well-tolerated, and recommended diagnostic tool for infants with or without FGD.
  • Normal RAIR was consistently observed in healthy infants, supporting its utility in this age group.
Abstract

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