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Updated: Oct 14, 2025

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Murine Full-thickness Skin Transplantation
Published on: January 2, 2017
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Management of full-thickness skin grafts
Mitchell Davis1, Daniel Baird2, Dane Hill2
1Department of Internal Medicine, HCA Las Palmas Del Sol Healthcare, El Paso, Texas.
Summary
For full-thickness skin grafts after Mohs surgery, absorbable plain gut sutures offer better outcomes. Plain white petrolatum is the safest topical emollient, minimizing allergic reactions.
Area of Science:
- Dermatology
- Plastic Surgery
- Wound Healing
Background:
- Full-thickness skin grafts are essential for reconstruction after Mohs surgery.
- Optimal graft management techniques, including suturing, securing, and postoperative dressing, remain debated.
- Evidence-based guidelines for these practices are needed.
Purpose of the Study:
- To review and synthesize current literature on the management of full-thickness skin grafts.
- To evaluate different suturing techniques, graft-securing methods, and topical emollient applications.
- To identify best practices for postoperative graft care.
Main Methods:
- Systematic literature review of studies on full-thickness skin graft management.
- Analysis of techniques for graft suturing, fixation, and postoperative topical treatments.
- Comparison of outcomes associated with different methods.
Main Results:
- Absorbable sutures, specifically plain gut, are associated with preferable outcomes.
- The tie-over bolster is a common method for securing grafts, with alternatives like polyurethane foam, sandwich, and quilting sutures also showing efficacy.
- Plain white petrolatum is the least likely topical emollient to cause allergic contact dermatitis.
Conclusions:
- Plain gut sutures represent an optimal choice for full-thickness skin grafts.
- Various effective methods exist for securing skin grafts, with the tie-over bolster being widely used.
- Plain white petrolatum is recommended as a safe postoperative emollient to prevent adverse skin reactions.
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