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Updated: Oct 14, 2025

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
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Comparison of Renal Function Between Tenofovir Disoproxil Fumarate and Other Nucleos(t)ide Reverse Transcriptase

Matthew G Fischer1, William Newman1, Kimberly Hammer1

  • 1At the time of the study, was Chief of Endocrinology and was a Pharmacy Resident; is Associate Chief of Staff/Research and Development; is Chief of Pharmacy; is Chief of Infectious Disease; all at Fargo Veterans Affairs Health Care System in North Dakota. Kimberly Hammer is Associate Professor, Internal Medicine Department, University of North Dakota School of Medicine and Health Sciences. Matthew Fischer is a Clinical Pharmacy Practitioner at Veterans Affairs Northern California Health Care System in Mather.

Federal Practitioner : for the Health Care Professionals of the VA, Dod, and PHS
|November 4, 2021
PubMed
Summary

Tenofofovir disoproxil fumarate (TDF) did not show a greater association with kidney injury compared to other nucleoside reverse transcriptase inhibitors (NRTIs) in patients with hepatitis B virus (HBV). Further research is needed to confirm these findings in HBV patients.

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