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Interplay Between Skin Microbiota Dysbiosis and the Host Immune System in Psoriasis: Potential Pathogenesis

Xiaoqian Liang1, Caixin Ou1, Jiayi Zhuang1

  • 1Department of Dermatology, Dermatology Hospital of Southern Medical University, Guangzhou, China.

Frontiers in Immunology
|November 4, 2021
PubMed

Insights

Altered skin microbiota may trigger psoriasis by interacting with innate immunity, leading to immune responses. Understanding this link offers new treatment avenues for this immune-mediated skin disease.

Area of Science:

  • Dermatology
  • Immunology
  • Microbiology

Background:

  • Psoriasis is a complex immune-mediated skin condition with limited treatment options due to incomplete understanding of its pathogenesis.
  • The role of skin microbiota in immune-mediated inflammatory skin diseases is a growing area of research.

Purpose of the Study:

  • To explore the potential role of skin microbiota in the immunopathogenesis of psoriasis.
  • To provide insights into novel therapeutic and preventive strategies for psoriasis.

Main Methods:

  • Literature review and discussion of current research on skin microbiota and psoriasis.
  • Postulation of mechanisms involving skin microbiota, innate immunity (antimicrobial peptides, Toll-like receptors), and T-cell activation.

Main Results:

  • Skin microbiota alterations may contribute to psoriasis development and exacerbation.
  • A proposed interplay between skin microbiota and innate immunity can stimulate T-cell responses, driving psoriatic inflammation.

Conclusions:

  • Understanding the skin microbiota's role in psoriasis pathogenesis is crucial for developing new treatments.
  • Targeting skin microbiota presents a promising avenue for future psoriasis therapies and prevention.
Keywords:
Th17immunologyinflammationpathogenesispsoriasisskin microbiota

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