Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

479
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
479
Carbohydrate Metabolism01:36

Carbohydrate Metabolism

12.6K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
12.6K
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

3.2K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
3.2K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

2.1K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
2.1K
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

81
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
81
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

3.6K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
3.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Scalable Left Ventricular ROI Annotation for Stress Perfusion Cardiac MRI using Deep Learning with Visual Refinement.

Journal of imaging informatics in medicine·2026
Same author

<i>Radiology: Cardiothoracic Imaging</i> Highlights 2025.

Radiology. Cardiothoracic imaging·2026
Same author

Prognostic value of pulmonary transit time by cardiovascular MRI in heart failure with preserved ejection fraction.

Heart (British Cardiac Society)·2026
Same author

Vasoactive breathing manoeuvres as an effective coronary vasodilator in patients with suspected coronary artery disease: a prospective comparative oxygenation-sensitive CMR study.

European heart journal. Imaging methods and practice·2026
Same author

Fast and scalable annotation-free LV-centered ROI localisation in stress perfusion cardiac MRI.

Computers in biology and medicine·2026
Same author

Predictors of Long-Term Outcomes in Hypertrophic Cardiomyopathy: The NHLBI HCM Registry.

JAMA·2026

Related Experiment Video

Updated: Oct 14, 2025

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model
06:22

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

Published on: November 29, 2024

859

Interrelationship between micronutrients and cardiovascular structure and function in type 2 diabetes.

Grace W M Walters1,2, Emma Redman2,3, Gaurav S Gulsin1,2

  • 1Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.

Journal of Nutritional Science
|November 4, 2021
PubMed
Summary

Micronutrient levels in type 2 diabetes (T2D) patients showed differences compared to controls. A meal replacement plan (MRP) increased certain vitamins but did not improve cardiovascular health in T2D individuals.

Keywords:
BMI, body mass indexCMRCMR, cardiac magnetic resonance imagingCVD, cardiovascular diseaseCardiovascular functionEF, ejection fractionHF, heart failureLV, left ventricularLow calorieLow-energy meal replacement planMRP, meal replacement planMicronutrientsPLP, pyridoxal 5-phosphateRCT, randomised control trialT2D, type 2 diabetesType 2 diabetes

More Related Videos

Combined Intravital Microscopy and Contrast-enhanced Ultrasonography of the Mouse Hindlimb to Study Insulin-induced Vasodilation and Muscle Perfusion
08:22

Combined Intravital Microscopy and Contrast-enhanced Ultrasonography of the Mouse Hindlimb to Study Insulin-induced Vasodilation and Muscle Perfusion

Published on: March 20, 2017

8.9K
Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations
08:21

Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations

Published on: July 21, 2023

1.5K

Related Experiment Videos

Last Updated: Oct 14, 2025

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model
06:22

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

Published on: November 29, 2024

859
Combined Intravital Microscopy and Contrast-enhanced Ultrasonography of the Mouse Hindlimb to Study Insulin-induced Vasodilation and Muscle Perfusion
08:22

Combined Intravital Microscopy and Contrast-enhanced Ultrasonography of the Mouse Hindlimb to Study Insulin-induced Vasodilation and Muscle Perfusion

Published on: March 20, 2017

8.9K
Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations
08:21

Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations

Published on: July 21, 2023

1.5K

Area of Science:

  • Cardiovascular Health
  • Nutritional Science
  • Metabolic Disorders

Background:

  • Micronutrients are vital for cardiovascular function.
  • Type 2 diabetes (T2D) is linked to increased cardiovascular disease risk, potentially involving micronutrient status.
  • Understanding micronutrient roles in T2D-related heart conditions is crucial.

Purpose of the Study:

  • To compare micronutrient status between individuals with T2D and healthy controls.
  • To evaluate changes in micronutrient status after a nutritionally complete meal replacement plan (MRP) versus routine care in T2D patients.
  • To determine if observed micronutrient changes correlate with alterations in cardiovascular structure or function.

Main Methods:

  • Secondary analysis of a prospective, randomized, blinded endpoint trial (NCT02590822).
  • Collected anthropometrics, cardiac MRI, and blood samples for vitamins B1, B6, B12, D, C, iron, and ferritin at baseline and 12 weeks.
  • Compared T2D participants (n=83) with healthy controls (n=36) at baseline; intervention groups included MRP (n=24) and routine care (n=30).

Main Results:

  • At baseline, T2D patients had higher vitamin B1 and lower vitamin B6 levels compared to controls.
  • All participants maintained micronutrient levels within reference ranges.
  • Following the MRP, increases in vitamins B1, B6, D, and C were observed, but these changes were not linked to improvements in cardiovascular structure or function.

Conclusions:

  • Micronutrient status differs between individuals with T2D and healthy controls.
  • A meal replacement plan can alter specific vitamin levels in T2D patients.
  • Changes in micronutrient status following the MRP intervention were not independently associated with improvements in cardiovascular structure or function in this T2D cohort.