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Metabolic Reprogramming in Kidney Diseases: Evidence and Therapeutic Opportunities

Yin Li1, Zixin Sha2, Hui Peng1

  • 1Department of Nephrology, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.

International Journal of Nephrology
|November 4, 2021
PubMed

Insights

Renal cells can reprogram metabolism after kidney injury, impacting disease progression. Understanding metabolic reprogramming offers new therapeutic strategies for kidney diseases.

Area of Science:

  • Nephrology
  • Metabolic pathways
  • Cellular adaptation

Background:

  • Metabolic reprogramming, initially observed in cancer cells, involves adapting metabolism to environmental changes for energy and proliferation.
  • Recent research indicates renal cells also undergo metabolic reprogramming following kidney injury.
  • Different kidney diseases are associated with distinct patterns of metabolic reprogramming in renal cells.

Purpose of the Study:

  • To review the role of metabolic reprogramming in kidney diseases.
  • To discuss the contribution of metabolic reprogramming to the pathophysiology of kidney diseases.
  • To explore novel therapeutic approaches targeting metabolic reprogramming in kidney diseases.

Main Methods:

  • Literature review of studies on kidney diseases and metabolic reprogramming.
  • Analysis of the role of metabolic adaptation in renal cell injury.
  • Synthesis of current understanding of metabolic reprogramming in kidney disease progression and prognosis.

Main Results:

  • Metabolic reprogramming is a key feature in the pathophysiology of various kidney diseases.
  • Renal cell metabolic adaptation is crucial after kidney injury.
  • Specific metabolic reprogramming patterns correlate with different kidney disease types.

Conclusions:

  • Metabolic reprogramming is integral to kidney disease development and progression.
  • Targeting metabolic pathways presents a promising avenue for novel kidney disease treatments.
  • Further research into renal cell metabolism is essential for advancing nephrology therapeutics.

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